An iminocoumarin-Cu(ii) ensemble-based chemodosimeter toward thiols

Hyo Sung Jung; Ji Hye Han; Yoichi Habata; Chulhun Kang; Jong Seung Kim

doi:10.1039/c1cc10672d

An iminocoumarin-Cu(ii) ensemble-based chemodosimeter toward thiols

Hyo Sung Jung, Ji Hye Han, Yoichi Habata, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

154 Citations (Scopus)

Abstract

An ‘ensemble’-based fluoregenic chemodosimeter 1-Cu(ii) for detection of thiols is reported. Complex 1-Cu(ii) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(ii) is also herewith demonstrated for cellular thiol detection in HepG2 cells.

Original language	English
Pages (from-to)	5142-5144
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	18
DOIs	https://doi.org/10.1039/c1cc10672d
Publication status	Published - 2011 Apr 19

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc10672d

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abstract = "An {\textquoteleft}ensemble{\textquoteright}-based fluoregenic chemodosimeter 1-Cu(ii) for detection of thiols is reported. Complex 1-Cu(ii) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(ii) is also herewith demonstrated for cellular thiol detection in HepG2 cells.",

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AU - Jung, Hyo Sung

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AU - Habata, Yoichi

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2011/4/19

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AB - An ‘ensemble’-based fluoregenic chemodosimeter 1-Cu(ii) for detection of thiols is reported. Complex 1-Cu(ii) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(ii) is also herewith demonstrated for cellular thiol detection in HepG2 cells.

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An iminocoumarin-Cu(ii) ensemble-based chemodosimeter toward thiols

Abstract

ASJC Scopus subject areas

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