TY - GEN
T1 - An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)
AU - Jung, W.
AU - Han, J.
AU - Kai, J.
AU - Lim, J. Y.
AU - Sul, D.
AU - Ahn, C. H.
PY - 2013
Y1 - 2013
N2 - A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.
AB - A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.
UR - http://www.scopus.com/inward/record.url?scp=84875440887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875440887&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2013.6474430
DO - 10.1109/MEMSYS.2013.6474430
M3 - Conference contribution
AN - SCOPUS:84875440887
SN - 9781467356558
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 1053
EP - 1056
BT - IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
T2 - IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Y2 - 20 January 2013 through 24 January 2013
ER -