An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

W. Jung, J. Han, J. Kai, J. Y. Lim, D. Sul, C. H. Ahn

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.

    Original languageEnglish
    Title of host publicationIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
    Pages1053-1056
    Number of pages4
    DOIs
    Publication statusPublished - 2013
    EventIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 - Taipei, Taiwan, Province of China
    Duration: 2013 Jan 202013 Jan 24

    Publication series

    NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
    ISSN (Print)1084-6999

    Other

    OtherIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
    Country/TerritoryTaiwan, Province of China
    CityTaipei
    Period13/1/2013/1/24

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Mechanical Engineering
    • Electrical and Electronic Engineering

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