An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

W. Jung; J. Han; J. Kai; J. Y. Lim; D. Sul; C. H. Ahn

doi:10.1109/MEMSYS.2013.6474430

An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

W. Jung, J. Han, J. Kai, J. Y. Lim, D. Sul, C. H. Ahn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.

Original language	English
Title of host publication	IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Pages	1053-1056
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2013.6474430
Publication status	Published - 2013
Event	IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 - Taipei, Taiwan, Province of China Duration: 2013 Jan 20 → 2013 Jan 24

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Country/Territory	Taiwan, Province of China
City	Taipei
Period	13/1/20 → 13/1/24

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2013.6474430

Cite this

Jung, W., Han, J., Kai, J., Lim, J. Y., Sul, D., & Ahn, C. H. (2013). An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). In IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 (pp. 1053-1056). [6474430] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2013.6474430

An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). / Jung, W.; Han, J.; Kai, J. et al.
IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013. 2013. p. 1053-1056 6474430 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jung, W, Han, J, Kai, J, Lim, JY, Sul, D & Ahn, CH 2013, An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). in IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013., 6474430, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 1053-1056, IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013, Taipei, Taiwan, Province of China, 13/1/20. https://doi.org/10.1109/MEMSYS.2013.6474430

Jung W, Han J, Kai J, Lim JY, Sul D, Ahn CH. An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). In IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013. 2013. p. 1053-1056. 6474430. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2013.6474430

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abstract = "A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.",

author = "W. Jung and J. Han and J. Kai and Lim, {J. Y.} and D. Sul and Ahn, {C. H.}",

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AU - Sul, D.

AU - Ahn, C. H.

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An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

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