An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles

Sung Jong Kim; Seung Woo Lee; Jin Dong Song; Young Wan Kwon; Kyung Jin Lee; Hyun Cheol Koo

doi:10.1016/j.snb.2017.09.108

An InSb-based magnetoresistive biosensor using Fe₃O₄ nanoparticles

Sung Jong Kim
, Seung Woo Lee
, Jin Dong Song
, Young Wan Kwon
, Kyung Jin Lee
, Hyun Cheol Koo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe₃O₄ nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.

Original language	English
Pages (from-to)	2894-2899
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	255
DOIs	https://doi.org/10.1016/j.snb.2017.09.108
Publication status	Published - 2018 Feb

Bibliographical note

Funding Information:
This work was supported by KIST and KU-KIST Institutional Programs, National Research Council of Science & Technology (NST) grant (No. CAP-16-01-KIST ), and National Research Foundation of Korea (NRF) grant (No. NRF-2017R1C1B2004765 ) of the Korean government (MSIP).

Publisher Copyright:
© 2017 Elsevier B.V.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antigen-antibody reaction
Biosensor
InSb
Magnetoresistive sensor
Nanoparticle

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

Access to Document

10.1016/j.snb.2017.09.108

Cite this

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title = "An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles",

abstract = "A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe3O4 nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.",

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note = "Funding Information: This work was supported by KIST and KU-KIST Institutional Programs, National Research Council of Science \& Technology (NST) grant (No. CAP-16-01-KIST ), and National Research Foundation of Korea (NRF) grant (No. NRF-2017R1C1B2004765 ) of the Korean government (MSIP). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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AU - Kwon, Young Wan

AU - Lee, Kyung Jin

AU - Koo, Hyun Cheol

N1 - Funding Information: This work was supported by KIST and KU-KIST Institutional Programs, National Research Council of Science & Technology (NST) grant (No. CAP-16-01-KIST ), and National Research Foundation of Korea (NRF) grant (No. NRF-2017R1C1B2004765 ) of the Korean government (MSIP). Publisher Copyright: © 2017 Elsevier B.V. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2018/2

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N2 - A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe3O4 nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.

AB - A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe3O4 nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.

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KW - InSb

KW - Magnetoresistive sensor

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