Abstract
Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.
Original language | English |
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Pages (from-to) | 1351-1357 |
Number of pages | 7 |
Journal | Neural Regeneration Research |
Volume | 9 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2014 Jul 15 |
Keywords
- Axon diameter
- Histology
- Inside-out vein autograft
- Myelin sheath thickness
- Myelinated axons
- Nerve regeneration
- Neural regeneration
- Peripheral nerve injury
- Platelet-rich plasma
- Sciatic nerve
- Sciatic nerve index
ASJC Scopus subject areas
- Developmental Neuroscience