An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells

Jong Min Lee; Ji Eun Kim; Edward Kang; Sang Hoon Lee; Bong Geun Chung

doi:10.1002/elps.201100161

An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells

Jong Min Lee, Ji Eun Kim, Edward Kang, Sang Hoon Lee, Bong Geun Chung

Department of Bio-convergence Engineering

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We developed an integrated microfluidic culture device to regulate embryonic stem (ES) cell fate. The integrated microfluidic culture device consists of an air control channel and a fluidic channel with 4×4 micropillar arrays. We hypothesized that the microscale posts within the micropillar arrays would enable the control of uniform cell docking and shear stress profiles. We demonstrated that ES cells cultured for 6 days in the integrated microfluidic culture device differentiated into endothelial cells. Therefore, our integrated microfluidic culture device is a potentially powerful tool for directing ES cell fate.

Original language	English
Pages (from-to)	3133-3137
Number of pages	5
Journal	Electrophoresis
Volume	32
Issue number	22
DOIs	https://doi.org/10.1002/elps.201100161
Publication status	Published - 2011 Nov

Keywords

Embryonic stem cell
Endothelial cell differentiation
Integrated microfluidic device

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Clinical Biochemistry

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10.1002/elps.201100161

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abstract = "We developed an integrated microfluidic culture device to regulate embryonic stem (ES) cell fate. The integrated microfluidic culture device consists of an air control channel and a fluidic channel with 4×4 micropillar arrays. We hypothesized that the microscale posts within the micropillar arrays would enable the control of uniform cell docking and shear stress profiles. We demonstrated that ES cells cultured for 6 days in the integrated microfluidic culture device differentiated into endothelial cells. Therefore, our integrated microfluidic culture device is a potentially powerful tool for directing ES cell fate.",

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AU - Lee, Sang Hoon

AU - Chung, Bong Geun

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An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells

Abstract

Keywords

ASJC Scopus subject areas

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