An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells

Jong Min Lee, Ji Eun Kim, Edward Kang, Sang Hoon Lee, Bong Geun Chung

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    We developed an integrated microfluidic culture device to regulate embryonic stem (ES) cell fate. The integrated microfluidic culture device consists of an air control channel and a fluidic channel with 4×4 micropillar arrays. We hypothesized that the microscale posts within the micropillar arrays would enable the control of uniform cell docking and shear stress profiles. We demonstrated that ES cells cultured for 6 days in the integrated microfluidic culture device differentiated into endothelial cells. Therefore, our integrated microfluidic culture device is a potentially powerful tool for directing ES cell fate.

    Original languageEnglish
    Pages (from-to)3133-3137
    Number of pages5
    JournalElectrophoresis
    Volume32
    Issue number22
    DOIs
    Publication statusPublished - 2011 Nov

    Keywords

    • Embryonic stem cell
    • Endothelial cell differentiation
    • Integrated microfluidic device

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Clinical Biochemistry

    Fingerprint

    Dive into the research topics of 'An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells'. Together they form a unique fingerprint.

    Cite this