Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Junghyo Yoon; Nuriye Korkmaz Zirpel; Hyun Ji Park; Sewoon Han; Kyung Hoon Hwang; Jisoo Shin; Seung Woo Cho; Chang Hoon Nam; Seok Chung

doi:10.1002/adhm.201500534

Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Junghyo Yoon, Nuriye Korkmaz Zirpel, Hyun Ji Park, Sewoon Han, Kyung Hoon Hwang, Jisoo Shin, Seung Woo Cho, Chang Hoon Nam, Seok Chung

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

Original language	English
Pages (from-to)	205-212
Number of pages	8
Journal	Advanced Healthcare Materials
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/adhm.201500534
Publication status	Published - 2016 Jan 1

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Angiogenesis
Bacteriophages
Collagen
Growth factors, VEGF

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.201500534

Cite this

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title = "Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors",

abstract = "Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.",

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author = "Junghyo Yoon and {Korkmaz Zirpel}, Nuriye and Park, {Hyun Ji} and Sewoon Han and Hwang, {Kyung Hoon} and Jisoo Shin and Cho, {Seung Woo} and Nam, {Chang Hoon} and Seok Chung",

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month = jan,

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doi = "10.1002/adhm.201500534",

language = "English",

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T1 - Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

AU - Yoon, Junghyo

AU - Korkmaz Zirpel, Nuriye

AU - Park, Hyun Ji

AU - Han, Sewoon

AU - Hwang, Kyung Hoon

AU - Shin, Jisoo

AU - Cho, Seung Woo

AU - Nam, Chang Hoon

AU - Chung, Seok

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

AB - Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

KW - Angiogenesis

KW - Bacteriophages

KW - Collagen

KW - Growth factors, VEGF

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DO - 10.1002/adhm.201500534

M3 - Article

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AN - SCOPUS:84956643889

SN - 2192-2640

VL - 5

SP - 205

EP - 212

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 2

ER -

Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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