Anthocyanins accelerate the healing of naproxen-induced gastric ulcer in rats by activating antioxidant enzymes via modulation of Nrf2

Sun Joong Kim, Jee Min Kim, So Hee Shim, Hyo Ihl Chang

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    The antioxidant and anti-inflammatory activities of anthocyanins enable them to inhibit the pathogenesis of gastric ulcer, but little is currently known about the underlying mechanisms behind this function. In this study, both in vitro and in vivo experiments were performed to investigate the palliative effects of anthocyanins on gastric ulcer, which was experimentally induced in rats by administrating 80. mg/kg (body weight) of naproxen. Our results indicated ROS generated after administrating naproxen were effectively eliminated by anthocyanins treatment, thereby relieving oxidative stress. Also, the anthocyanins treatment resulted in a significantly reduced TBARS level and increased levels of antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Furthermore, anthocyanins increased the Nrf2 as well as GI-GPx activities via nuclear translocation and binding of Nrf2 to the antioxidant response elements (ARE) regions in the GI-GPx promoter. Thus, anthocyanins seem to be appropriate target for gastric ulcer therapy.

    Original languageEnglish
    Pages (from-to)569-579
    Number of pages11
    JournalJournal of Functional Foods
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 2014

    Bibliographical note

    Funding Information:
    This work was supported in part by the Korea University Grant.

    Keywords

    • Anthocyanins
    • Anti-ulcer
    • GI-GPx
    • NSAID
    • Nrf2

    ASJC Scopus subject areas

    • Food Science
    • Medicine (miscellaneous)
    • Nutrition and Dietetics

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