Anti-adhesive Effect and Safety of Sodium Hyaluronate and Sodium Carboxymethyl Cellulose Solution in Thyroid Surgery

Yoo Seung Chung, Kyu Eun Lee, Hoon Yub Kim, Jun Ho Choe, Yeo Kyu Youn, Won Seo Park, Suck Hwan Koh

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Objective: A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the anti-adhesive effect and safety of a newly developed HA-CMC solution in thyroidectomy. Methods: Seventy-four patients who underwent thyroidectomy were prospectively randomized. In the study group of 38 patients, 5 mL HA-CMC solution was applied to the operative field after thyroidectomy. The subjects were asked about adhesive symptoms using a four-item questionnaire at 2 weeks, 2 months and 6 months after surgery. In addition, three items on the appearance of neck wrinkles and scars were evaluated by a physician. Each item was scored from 0 to 10. Results: The mean (± standard deviation) total adhesion score at each visit was 15.22 ± 8.99, 10.42 ± 8.41, and 7.24 ± 5.83 for the control group and 19.29 ± 9.71, 9.46 ± 5.71, and 6.03 ± 4.32 for the study group. Total adhesion scores for both groups decreased with time (p < 0.001), but no significant differences were noted between the two groups (p > 0.066). There were no complications related to the HA-CMC solution. Conclusion: The HA-CMC solution did not decrease subjective or objective postoperative adhesion in patients undergoing thyroid surgery, although it was biologically safe.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalAsian Journal of Surgery
Issue number1
Publication statusPublished - 2010 Jan
Externally publishedYes


  • anti-adhesive agents
  • postoperative adhesion
  • sodium hyaluronate carboxymethyl cellulose
  • thyroidectomy

ASJC Scopus subject areas

  • Surgery


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