Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian

Mirae An; Miae Oh; Keun Tae Park; Ki Hwan Seon; Jeong Eun Jo; Seong Kweon Lee; Jeong Keun Kim; Kwang Soon Shin; Jong Ho Koh; Young Hee Lim

doi:10.1007/s10068-021-00955-3

Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian

Mirae An, Miae Oh, Keun Tae Park, Ki Hwan Seon, Jeong Eun Jo, Seong Kweon Lee, Jeong Keun Kim, Kwang Soon Shin, Jong Ho Koh, Young Hee Lim

School of Biosystem and Biomedical Science

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.

Original language	English
Pages (from-to)	1257-1268
Number of pages	12
Journal	Food Science and Biotechnology
Volume	30
Issue number	9
DOIs	https://doi.org/10.1007/s10068-021-00955-3
Publication status	Published - 2021 Sept

Bibliographical note

Publisher Copyright:
© 2021, The Korean Society of Food Science and Technology.

Keywords

Anti-asthma
Anti-inflammation
Antitussive
Fermented extract of medicinal plant

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.1007/s10068-021-00955-3

Cite this

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title = "Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian",

abstract = "Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.",

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author = "Mirae An and Miae Oh and Park, {Keun Tae} and Seon, {Ki Hwan} and Jo, {Jeong Eun} and Lee, {Seong Kweon} and Kim, {Jeong Keun} and Shin, {Kwang Soon} and Koh, {Jong Ho} and Lim, {Young Hee}",

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doi = "10.1007/s10068-021-00955-3",

language = "English",

volume = "30",

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AU - An, Mirae

AU - Oh, Miae

AU - Park, Keun Tae

AU - Seon, Ki Hwan

AU - Jo, Jeong Eun

AU - Lee, Seong Kweon

AU - Kim, Jeong Keun

AU - Shin, Kwang Soon

AU - Koh, Jong Ho

AU - Lim, Young Hee

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N2 - Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.

AB - Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.

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Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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