Anti-glycation effect of gold nanoparticles on collagen

Ji Hoon Kim; Chung Oui Hong; Yun Chang Koo; Hee Don Choi; Kwang Won Lee

doi:10.1248/bpb.35.260

Anti-glycation effect of gold nanoparticles on collagen

Ji Hoon Kim, Chung Oui Hong, Yun Chang Koo, Hee Don Choi, Kwang Won Lee

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

Original language	English
Pages (from-to)	260-264
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	35
Issue number	2
DOIs	https://doi.org/10.1248/bpb.35.260
Publication status	Published - 2012 Feb

Keywords

Aging
Collagen
Dermis
Glycation
Gold nanoparticle

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.35.260

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AU - Kim, Ji Hoon

AU - Hong, Chung Oui

AU - Koo, Yun Chang

AU - Choi, Hee Don

AU - Lee, Kwang Won

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Anti-glycation effect of gold nanoparticles on collagen

Abstract

Keywords

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