Abstract
An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.
Original language | English |
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Pages (from-to) | 2222-2233 |
Number of pages | 12 |
Journal | Marine drugs |
Volume | 10 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2012 Oct |
Externally published | Yes |
Keywords
- Antiviral activity
- Human rhinovirus
- Neorhodomela aculeate
- Polybromocatechol compounds
- Red alga
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Pharmaceutical Science