Anti-inflammatory constituents from the fruits of Vitex rotundifolia

Chul Lee; Jin Woo Lee; Qinghao Jin; Hak Ju Lee; Sung Joon Lee; Dongho Lee; Myung Koo Lee; Chong Kil Lee; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2013.08.004

Anti-inflammatory constituents from the fruits of Vitex rotundifolia

Chul Lee, Jin Woo Lee, Qinghao Jin, Hak Ju Lee, Sung Joon Lee, Dongho Lee, Myung Koo Lee, Chong Kil Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC₅₀ values ranging from 11.3 to 24.5 μM.

Original language	English
Pages (from-to)	6010-6014
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2013.08.004
Publication status	Published - 2013 Nov 1

Keywords

Diterpene
Neolignan
Nitric oxide
Verbenaceae
Vitex rotundifolia

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.08.004

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title = "Anti-inflammatory constituents from the fruits of Vitex rotundifolia",

abstract = "Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5 μM.",

keywords = "Diterpene, Neolignan, Nitric oxide, Verbenaceae, Vitex rotundifolia",

author = "Chul Lee and Lee, {Jin Woo} and Qinghao Jin and Lee, {Hak Ju} and Lee, {Sung Joon} and Dongho Lee and Lee, {Myung Koo} and Lee, {Chong Kil} and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This research was financially supported by the Korean Forest Service (Forest Science & Technology Project No. S120912L020120 ), the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT). ",

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doi = "10.1016/j.bmcl.2013.08.004",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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AU - Lee, Chul

AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Lee, Hak Ju

AU - Lee, Sung Joon

AU - Lee, Dongho

AU - Lee, Myung Koo

AU - Lee, Chong Kil

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was financially supported by the Korean Forest Service (Forest Science & Technology Project No. S120912L020120 ), the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT).

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5 μM.

AB - Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5 μM.

KW - Diterpene

KW - Neolignan

KW - Nitric oxide

KW - Verbenaceae

KW - Vitex rotundifolia

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Anti-inflammatory constituents from the fruits of Vitex rotundifolia

Abstract

Keywords

ASJC Scopus subject areas

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