Anti-inflammatory constituents from the fruits of Vitex rotundifolia

Chul Lee, Jin Woo Lee, Qinghao Jin, Hak Ju Lee, Sung Joon Lee, Dongho Lee, Myung Koo Lee, Chong Kil Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5 μM.

Original languageEnglish
Pages (from-to)6010-6014
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number21
Publication statusPublished - 2013 Nov 1

Bibliographical note

Funding Information:
This research was financially supported by the Korean Forest Service (Forest Science & Technology Project No. S120912L020120 ), the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT).


  • Diterpene
  • Neolignan
  • Nitric oxide
  • Verbenaceae
  • Vitex rotundifolia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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