Anti-inflammatory constituents from the fruits of Vitex rotundifolia

Chul Lee, Jin Woo Lee, Qinghao Jin, Hak Ju Lee, Sung Joon Lee, Dongho Lee, Myung Koo Lee, Chong Kil Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

    Research output: Contribution to journalArticlepeer-review

    50 Citations (Scopus)

    Abstract

    Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5 μM.

    Original languageEnglish
    Pages (from-to)6010-6014
    Number of pages5
    JournalBioorganic and Medicinal Chemistry Letters
    Volume23
    Issue number21
    DOIs
    Publication statusPublished - 2013 Nov 1

    Bibliographical note

    Funding Information:
    This research was financially supported by the Korean Forest Service (Forest Science & Technology Project No. S120912L020120 ), the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT).

    Keywords

    • Diterpene
    • Neolignan
    • Nitric oxide
    • Verbenaceae
    • Vitex rotundifolia

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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