Abstract
Inflammatory bowel diseases (IBDs) are chronic disorders that are characterized by intestinal epithelial inflammation and injury. Currently, the most employed therapies are antibiotics and anti-inflammatory drugs; however, the side effects limit long-term effectiveness. We evaluated the impact of glucose-lysine Maillard reaction products (Glc-Lys MRPs) on colitis, induced in rats by an administration of 5% dextran sulfate sodium (DSS) in drinking water. Glc-Lys MRPs ameliorate DSS-induced colitis, as determined by a decrease in disease index activity, colon weight/length ratio, nitric oxide levels in serum, recovery of body weight loss, colon length and serum lysozyme levels. Furthermore, Glc-Lys MRPs increase the glutathione content and the activity of glutathione peroxidase, superoxide dismutase and catalase, and inhibit lipid peroxidation and myeloperoxidase activity in colon tissues. In particular, Glc-Lys MRPs suppress the mRNA level of the inflammatory cytokines and nuclear factor-κB in colon tissues. This study suggests the potential of Glc-Lys MRPs in preventing or treating IBDs.
| Original language | English |
|---|---|
| Pages (from-to) | 324-332 |
| Number of pages | 9 |
| Journal | International Immunopharmacology |
| Volume | 52 |
| DOIs | |
| Publication status | Published - 2017 Nov |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2017R1A2B4012182 ) and Korea University Grant ( K1706241 ) and School of Life Sciences and Biotechnology for BK21 PLUS, Korea University. The authors thank the Korea University-CJ Food Safety Center (Seoul, South Korea) for providing the equipment and facilities.
Keywords
- Colitis
- Cytokines
- Dextran sulfate sodium
- Inflammatory bowel diseases
- Maillard reaction products
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology