Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra

Honghong Xing, Lijun An, Ziteng Song, Shanshan Li, Huimei Wang, Chunyan Wang, Jie Zhang, Muhetaer Tuerhong, Munira Abudukeremu, Dihua Li, Dongho Lee, Jing Xu, Namrita Lall, Yuanqiang Guo

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.

    Original languageEnglish
    Pages (from-to)2844-2853
    Number of pages10
    JournalJournal of Natural Products
    Volume83
    Issue number10
    DOIs
    Publication statusPublished - 2020 Oct 23

    Bibliographical note

    Publisher Copyright:
    © 2020 American Chemical Society and American Society of Pharmacognosy.

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Complementary and alternative medicine
    • Organic Chemistry

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