TY - JOUR
T1 - Anti-inflammatory Metabolites from Chaetomium nigricolor
AU - Kim, Min Jee
AU - Kim, Dong Cheol
AU - Kwon, Jaeyoung
AU - Ryu, Seung Mok
AU - Kwon, Haeun
AU - Guo, Yuanqiang
AU - Hong, Seung Beom
AU - Kim, Youn Chul
AU - Oh, Hyuncheol
AU - Lee, Dongho
N1 - Funding Information:
This research was financially supported by Korea University, Korea Polar Research Institute (PE19100), and the National Research Foundation of Korea (NRF-2019R1A2C1006226 and NRF-2019R1A4A1020626), Rural Development Administration (PJ01354902), and the KIST Program (2E30650 and 2Z06220).
Funding Information:
This research was financially supported by Korea University Korea Polar Research Institute (PE19100), and the National Research Foundation of Korea (NRF-2019R1A2C1006226 and NRF-2019R1A4A1020626) Rural Development Administration (PJ01354902), and the KIST Program (2E30650 and 2Z06220).
Publisher Copyright:
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.
PY - 2020/4/24
Y1 - 2020/4/24
N2 - Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-γ-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12.
AB - Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-γ-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12.
UR - http://www.scopus.com/inward/record.url?scp=85082326259&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.9b00560
DO - 10.1021/acs.jnatprod.9b00560
M3 - Article
C2 - 32163284
AN - SCOPUS:85082326259
SN - 0163-3864
VL - 83
SP - 881
EP - 887
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -