Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha

Bangjian Dong, Xueyuan Yang, Wenpei Liu, Lijun An, Xuke Zhang, Muhetaer Tuerhong, Qing Du, Chunyan Wang, Munira Abudukeremu, Jing Xu, Dongho Lee, Ling Shuai, Namrita Lall, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.

Original languageEnglish
Pages (from-to)894-904
Number of pages11
JournalJournal of Natural Products
Volume83
Issue number4
DOIs
Publication statusPublished - 2020 Apr 24

Bibliographical note

Funding Information:
This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin (No. 19JCYBJC28100), and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902).

Publisher Copyright:
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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