Anti-Menopausal Effect of Soybean Germ Extract and Lactobacillus gasseri in the Ovariectomized Rat Model

Sun Hee Lee, Tae Joong Lim, Eun Ju Yun, Kyoung Heon Kim, Sanghyun Lim

Research output: Contribution to journalArticlepeer-review


Menopause is a significant phase in a woman’s life. Menopausal symptoms can affect overall well-being and quality of life. Conventionally, hormone replacement therapy (HRT) is used to alleviate menopausal symptoms; however, depending on the conditions, HRT may lead to side effects, necessitating the exploration of alternative therapies with fewer side effects. In this study, we investigated the effects of a combination of soybean germ extract (S30) containing 30% (w/w) isoflavone and a probiotic, Lactobacillus gasseri (LGA1), on menopausal conditions in an ovariectomized (OVX) rat model. We evaluated the impact of S30+LGA on body weight, estrogen markers, uterine and bone health, vascular markers, and neurotransmitter levels. The results revealed that treatment with S30+LGA1 significantly improved body weight and uterine and bone health. Moreover, S30+LGA1 demonstrated promising effects on lipid profile, liver function, and vascular markers and positively impacted serotonin and norepinephrine levels, indicating potential mood-enhancing effects. In conclusion, S30+LGA1, possessing anti-menopausal effects in vitro and in vivo, can be recommended as a soy-based diet, which offers various health benefits, especially for menopausal women.

Original languageEnglish
Article number4485
Issue number20
Publication statusPublished - 2023 Oct

Bibliographical note

Publisher Copyright:
© 2023 by the authors.


  • aglycone
  • isoflavone
  • lactic acid bacteria
  • menopause
  • probiotics
  • soybean germ extract

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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