Abstract
In spite of recent advances in the treatment of retinoblastoma, chemotherapy is still challenging in high-stage intraocular retinoblastoma or metastatic retinoblastoma. Here, we investigated whether arginine deprivation via arginine deiminase (ADI) could be a new anti-tumor therapy in retinoblastoma cells. Expression of argininosuccinate synthetase (ASS) was detected in human retinoblastoma tissues. Even with a high expression of ASS, ADI effectively inhibited the proliferation of retinoblastoma cells and induced retinoblastoma cell death in a dose-dependent manner. These results indicate that arginine deprivation via ADI could be another treatment option for retinoblastoma due to low ASS activity in retinoblastoma cells.
Original language | English |
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Pages (from-to) | 1373-1377 |
Number of pages | 5 |
Journal | Oncology reports |
Volume | 18 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2007 Dec |
Keywords
- Arginine deiminase
- Arginine deprivation
- Argininosuccinate synthetase
- Retinoblastoma
ASJC Scopus subject areas
- Oncology
- Cancer Research