Anti-vasospastic effects of botulinum toxin B pretreatment in animal models

Jeongmin Yoon, Eul Sik Yoon, Byung Il Lee, Seung Ha Park, Jin Woo Kim

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    1 Citation (Scopus)


    Background: Botulinum toxin has been recently known for its vasodilatory effect. The main purpose of our study was to demonstrate the anti-vasospastic effect of botulinum toxin B in animal models. Method: In this prospective experimental rat study, we used 10 male Sprague-Dawley rats. The right and left inguinal areas (femoral vessels) served as the experimental and control groups, respectively. Three days prior to the experimental procedure, botulinum toxin B and normal saline were subcutaneously injected in the experimental and control groups, respectively. After three days, the vascular diameter and flow were measured. Then, phenylephrine was injected, and after one hour the same parameters were measured. Results: The changes in arterial diameter in the experimental and control group were 30.83 ± 10.43% and 40.00 ± 8.61%, respectively. The vein diameter decreased by 22.98 ± 10.08% in the experimental group compared to 49.05 ± 10.08% for the control group. Furthermore, the arterial flow change in the control group was 8.28 ± 2.10% compared to 1.16 ± 0.65% in the experimental group. In addition, the venous flow in the control group decreased by 9.27 ± 2.75% compared to 0.92 ± 0.56% in the experimental group. Both arterial and venous diameters and flows showed statistical significance between the experimental and control groups (p <.05). Conclusions: Our study demonstrated that pretreatment with botulinum toxin B led to significantly reduced change in vascular diameters and flows compared with the control group, supporting the anti-vasospastic effects of botulinum toxin B.

    Original languageEnglish
    Pages (from-to)25-30
    Number of pages6
    JournalJournal of Plastic Surgery and Hand Surgery
    Issue number1
    Publication statusPublished - 2019 Jan 2

    Bibliographical note

    Publisher Copyright:
    © 2018, © 2018 Acta Chirurgica Scandinavica Society.


    • Botulinum toxin
    • Flap
    • Vasospasm

    ASJC Scopus subject areas

    • Surgery


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