Antibacterial properties of main-chain cationic polymers prepared through amine-epoxy 'Click' polymerization

Junki Oh, Seung Jin Kim, Min Kyu Oh, Anzar Khan

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Poly(β-hydroxyl amine)s are prepared through an amine-epoxy 'click' polymerization process in water under ambient conditions. These materials could be subjected to a post-polymerization protonation/alkylation reaction at the nitrogen atom to yield quaternary ammonium salts in the polymer backbone. The antimicrobial activities indicated that polymers carrying butyl chains at the nitrogen atom are effective towards Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), as only 10-20 μg mL-1 polymer concentrations are required to inhibit the bacterial growth by >90%. One of the candidates was also found to be effective towards Mycobacterium smegmatis (M. smegmatis)-a model organism to develop drugs against rapidly spreading tuberculosis (TB) infections. The hemolysis assay indicated that a majority of antimicrobial agents did not disrupt red blood cell membranes. The mechanistic studies suggested that cell wall disruption by the cationic polymers was the likely cause of bacterial death.

Original languageEnglish
Pages (from-to)26752-26755
Number of pages4
JournalRSC Advances
Volume10
Issue number45
DOIs
Publication statusPublished - 2020 Jul 13

Bibliographical note

Funding Information:
This research was funded by National Research Foundation of Korea grant funded by the Korean government (MSIP) (NRF18R1D1A1B07048527).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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