Antibiotic Scars Left on the Gut Microbiota from the Stringent Response

Hyojeong Yi; Heenam Stanley Kim

doi:10.1016/j.tim.2018.06.003

Antibiotic Scars Left on the Gut Microbiota from the Stringent Response

Hyojeong Yi, Heenam Stanley Kim

Research output: Contribution to journal › Short survey › peer-review

7 Citations (Scopus)

Abstract

Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteria, should not be overlooked.

Original language	English
Pages (from-to)	735-737
Number of pages	3
Journal	Trends in Microbiology
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.tim.2018.06.003
Publication status	Published - 2018 Sept

Bibliographical note

Funding Information:
This work was supported by grants 2018M3A9F3055921 , 2018R1A2B2006456 , and 2015M3C9A4053393 from the National Research Foundation (NRF) of the Republic of Korea . Additional support was provided by grant 2016R1A6A3A11935950 for research fellows from the NRF of the Republic of Korea to HY.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

(p)ppGpp
antibiotic persistence
antibiotic tolerance
gut microbiota
stringent response

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2018.06.003

Cite this

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title = "Antibiotic Scars Left on the Gut Microbiota from the Stringent Response",

abstract = "Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteria, should not be overlooked.",

keywords = "(p)ppGpp, antibiotic persistence, antibiotic tolerance, gut microbiota, stringent response",

author = "Hyojeong Yi and Kim, {Heenam Stanley}",

note = "Funding Information: This work was supported by grants 2018M3A9F3055921 , 2018R1A2B2006456 , and 2015M3C9A4053393 from the National Research Foundation (NRF) of the Republic of Korea . Additional support was provided by grant 2016R1A6A3A11935950 for research fellows from the NRF of the Republic of Korea to HY. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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AU - Yi, Hyojeong

AU - Kim, Heenam Stanley

N1 - Funding Information: This work was supported by grants 2018M3A9F3055921 , 2018R1A2B2006456 , and 2015M3C9A4053393 from the National Research Foundation (NRF) of the Republic of Korea . Additional support was provided by grant 2016R1A6A3A11935950 for research fellows from the NRF of the Republic of Korea to HY. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/9

Y1 - 2018/9

N2 - Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteria, should not be overlooked.

AB - Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteria, should not be overlooked.

KW - (p)ppGpp

KW - antibiotic persistence

KW - antibiotic tolerance

KW - gut microbiota

KW - stringent response

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U2 - 10.1016/j.tim.2018.06.003

DO - 10.1016/j.tim.2018.06.003

M3 - Short survey

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AN - SCOPUS:85049905905

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VL - 26

SP - 735

EP - 737

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 9

ER -

Antibiotic Scars Left on the Gut Microbiota from the Stringent Response

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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