TY - JOUR
T1 - Antibiotics and antibiotic resistance genes in agricultural soils
T2 - A systematic analysis
AU - Wu, Jie
AU - Wang, Jinyang
AU - Li, Zhutao
AU - Guo, Shumin
AU - Li, Kejie
AU - Xu, Pinshang
AU - Ok, Yong Sik
AU - Jones, Davey L.
AU - Zou, Jianwen
N1 - Funding Information:
This research was financially supported by the National Natural Science Foundation of China (42177285; 42007072), the Fundamental Research Funds for the Central Universities (KJQN202119), and the Startup Foundation for Introducing Talent of Nanjing Agricultural University (030/804028). J.W. thanks the funding support from the Startup Foundation for Introducing Talent of Nanjing Agricultural University.
Funding Information:
J.W. thanks the funding support from the Startup Foundation for Introducing Talent of Nanjing Agricultural University.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Misuse and overuse of antibiotics have contributed to the rise of antimicrobial resistance as one of the top public health threats. Antibiotics and antibiotic resistance genes (ARGs) are prevalent in agricultural soils due to the widespread application of livestock and organic wastes. However, information about the occurrence, distribution, and risk of antibiotics and ARGs in agricultural soils is lacking for many scenarios. In this study, based on 2225 observations from 135 independent studies, we summarized the concentration or abundance of antibiotics or ARGs under different fertilizer sources and land-use patterns, analyzed the contributions of key environmental factors to the occurrence of antibiotics and ARGs in agricultural soils, and highlighted the potential ecological risk of typical antibiotics and the relationship between ARGs and mobile genetic elements (MGEs). Our results showed that cattle manure, chicken manure, swine manure, and sewage sludge were the primary pollution sources of antibiotics and ARGs in agricultural soils, and sulfonamides, tetracyclines, fluoroquinolones, and their corresponding ARGs were the main pollution types. Land-use type, soil, and climatic factors affected antibiotics concentration and ARG abundances. MGEs play a vital role in promoting the dissemination of ARGs, especially the sul1 gene is closely related to intI1. In conclusion, our findings and future research exploring these topics will contribute to better management of antibiotic and ARG contamination in agricultural soils and their risk to human health.
AB - Misuse and overuse of antibiotics have contributed to the rise of antimicrobial resistance as one of the top public health threats. Antibiotics and antibiotic resistance genes (ARGs) are prevalent in agricultural soils due to the widespread application of livestock and organic wastes. However, information about the occurrence, distribution, and risk of antibiotics and ARGs in agricultural soils is lacking for many scenarios. In this study, based on 2225 observations from 135 independent studies, we summarized the concentration or abundance of antibiotics or ARGs under different fertilizer sources and land-use patterns, analyzed the contributions of key environmental factors to the occurrence of antibiotics and ARGs in agricultural soils, and highlighted the potential ecological risk of typical antibiotics and the relationship between ARGs and mobile genetic elements (MGEs). Our results showed that cattle manure, chicken manure, swine manure, and sewage sludge were the primary pollution sources of antibiotics and ARGs in agricultural soils, and sulfonamides, tetracyclines, fluoroquinolones, and their corresponding ARGs were the main pollution types. Land-use type, soil, and climatic factors affected antibiotics concentration and ARG abundances. MGEs play a vital role in promoting the dissemination of ARGs, especially the sul1 gene is closely related to intI1. In conclusion, our findings and future research exploring these topics will contribute to better management of antibiotic and ARG contamination in agricultural soils and their risk to human health.
KW - Albert Juhasz and Scott Bradford
KW - Antibiotic resistance genes
KW - agricultural soil
KW - ecological risk
KW - environmental factors
KW - horizontal gene transfer
KW - veterinary antibiotic
UR - http://www.scopus.com/inward/record.url?scp=85133458863&partnerID=8YFLogxK
U2 - 10.1080/10643389.2022.2094693
DO - 10.1080/10643389.2022.2094693
M3 - Review article
AN - SCOPUS:85133458863
SN - 1064-3389
VL - 53
SP - 847
EP - 864
JO - Critical Reviews in Environmental Science and Technology
JF - Critical Reviews in Environmental Science and Technology
IS - 7
ER -