Anticariogenic activity of agarobiose and agarooligosaccharides derived from red macroalgae

Sora Yu, Eun Ju Yun, Dong Hyun Kim, So Young Park, Kyoung Heon Kim

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


3,6-Anhydro-L-galactose (AHG) produced from agarose in red macroalgae was recently suggested as an anticariogenic sugar to replace widely used xylitol. However, the multi-step process for obtaining monomeric sugar AHG from agarose may be expensive. Generally, it is easier to obtain oligosaccharides than monosaccharides from polysaccharides. Therefore, a one-step process to obtain agarobiose (AB) from agarose was recently developed, and here, we suggest AB as a new anticariogenic agent, owing to its anticariogenic activity against Streptococcus mutans. Among AHG-containing oligosaccharides, AB, neoagarobiose (NAB), agarooligosaccharides (AOSs), and neoagarooligosaccharides (NAOSs), AB showed higher inhibitory activity than AOSs against the growth and lactic acid production of S. mutans; no such inhibitory activity was observed for NAB and NAOSs. This inhibitory effect of AB was comparable to the previously reported inhibitory activity of AHG against S. mutans. These results suggest that AB, which can be more economically and simply produced than AHG, may serve as an anticariogenic sugar.

Original languageEnglish
Pages (from-to)7297-7303
Number of pages7
JournalJournal of agricultural and food chemistry
Issue number26
Publication statusPublished - 2019 Jul 3


  • Agar
  • Agarobiose
  • Agarooligosaccharides
  • Agarose
  • Anticariogenic
  • Dental caries
  • Red macroalgae
  • Streptococcus mutans

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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