Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim; Toshitaka Nabeshima; Wang Kee Jhoo; Kwang Ho Ko; Won Ki Kim; Eun Joo Shin; Minkyoung Cho; Phil Ho Lee

doi:10.1016/S0960-894X(01)00262-1

Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim, Toshitaka Nabeshima, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Eun Joo Shin, Minkyoung Cho, Phil Ho Lee

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

Original language	English
Pages (from-to)	1651-1654
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(01)00262-1
Publication status	Published - 2001 Jul 9
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the BK 21 project and a grant (1998-012-F00014) from the Korea Research Foundation, Republic of Korea.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00262-1

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abstract = "We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.",

author = "Kim, {Hyoung Chun} and Toshitaka Nabeshima and Jhoo, {Wang Kee} and Ko, {Kwang Ho} and Kim, {Won Ki} and Shin, {Eun Joo} and Minkyoung Cho and Lee, {Phil Ho}",

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T1 - Anticonvulsant effects of new morphinan derivatives

AU - Kim, Hyoung Chun

AU - Nabeshima, Toshitaka

AU - Jhoo, Wang Kee

AU - Ko, Kwang Ho

AU - Kim, Won Ki

AU - Shin, Eun Joo

AU - Cho, Minkyoung

AU - Lee, Phil Ho

N1 - Funding Information: This work was supported by the BK 21 project and a grant (1998-012-F00014) from the Korea Research Foundation, Republic of Korea.

PY - 2001/7/9

Y1 - 2001/7/9

N2 - We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

AB - We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

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U2 - 10.1016/S0960-894X(01)00262-1

DO - 10.1016/S0960-894X(01)00262-1

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JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Anticonvulsant effects of new morphinan derivatives

Abstract

Bibliographical note

ASJC Scopus subject areas

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