Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells

Mi Kyeong Lee; Ki Yong Lee; Hee Young Jeon; Sang Hyun Sung; Young Choong Kim

doi:10.3109/14756360902829709

Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells

Mi Kyeong Lee
, Ki Yong Lee
, Hee Young Jeon
, Sang Hyun Sung
, Young Choong Kim

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 μM.

Original language	English
Pages (from-to)	1276-1279
Number of pages	4
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	24
Issue number	6
DOIs	https://doi.org/10.3109/14756360902829709
Publication status	Published - 2009 Dec
Externally published	Yes

Keywords

Antifibrotic activity
Euscaphis japonica
Hepatic stellate cells
HSC-T6
Pomolic acid
Triterpenoid

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.3109/14756360902829709

Cite this

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title = "Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells",

abstract = "In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 μM.",

keywords = "Antifibrotic activity, Euscaphis japonica, Hepatic stellate cells, HSC-T6, Pomolic acid, Triterpenoid",

author = "Lee, \{Mi Kyeong\} and Lee, \{Ki Yong\} and Jeon, \{Hee Young\} and Sung, \{Sang Hyun\} and Kim, \{Young Choong\}",

year = "2009",

month = dec,

doi = "10.3109/14756360902829709",

language = "English",

volume = "24",

pages = "1276--1279",

journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",

issn = "1475-6366",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells

AU - Lee, Mi Kyeong

AU - Lee, Ki Yong

AU - Jeon, Hee Young

AU - Sung, Sang Hyun

AU - Kim, Young Choong

PY - 2009/12

Y1 - 2009/12

N2 - In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 μM.

AB - In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 μM.

KW - Antifibrotic activity

KW - Euscaphis japonica

KW - Hepatic stellate cells

KW - HSC-T6

KW - Pomolic acid

KW - Triterpenoid

UR - https://www.scopus.com/pages/publications/73949157094

U2 - 10.3109/14756360902829709

DO - 10.3109/14756360902829709

M3 - Article

C2 - 19807218

AN - SCOPUS:73949157094

SN - 1475-6366

VL - 24

SP - 1276

EP - 1279

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

IS - 6

ER -

Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells

Abstract

Keywords

ASJC Scopus subject areas

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