Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection

Ho Jun Lee, Sung Jin Han, Heezoo Kim, Il Ok Lee, Myoung Hoon Kong, Nan Suk Kim, Sang Ho Lim, Mi Kyoung Lee

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.

Original languageEnglish
Pages (from-to)879-882
Number of pages4
JournalJournal of Korean medical science
Issue number5
Publication statusPublished - 2009 Oct
Externally publishedYes


  • Antihistamine
  • Pain
  • Rocuronium

ASJC Scopus subject areas

  • General Medicine


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