Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Dahyun Hwang; Sung Pil Jo; Jiyun Lee; Jeong Keun Kim; Ki Hyun Kim; Young Hee Lim

doi:10.1016/j.jff.2015.09.039

Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Dahyun Hwang, Sung Pil Jo, Jiyun Lee, Jeong Keun Kim, Ki Hyun Kim, Young Hee Lim

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.

Original language	English
Pages (from-to)	353-362
Number of pages	10
Journal	Journal of Functional Foods
Volume	19
DOIs	https://doi.org/10.1016/j.jff.2015.09.039
Publication status	Published - 2015 Dec

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

Antihyperlipidaemia
Atherogenic index
Coronary artery risk index
Foam cell
Oxyresveratrol
Ramulus mori

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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10.1016/j.jff.2015.09.039

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title = "Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet",

abstract = "The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.",

keywords = "Antihyperlipidaemia, Atherogenic index, Coronary artery risk index, Foam cell, Oxyresveratrol, Ramulus mori",

author = "Dahyun Hwang and Jo, {Sung Pil} and Jiyun Lee and Kim, {Jeong Keun} and Kim, {Ki Hyun} and Lim, {Young Hee}",

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language = "English",

volume = "19",

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AU - Jo, Sung Pil

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AU - Kim, Jeong Keun

AU - Kim, Ki Hyun

AU - Lim, Young Hee

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AB - The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.

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KW - Atherogenic index

KW - Coronary artery risk index

KW - Foam cell

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ER -

Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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