Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Dahyun Hwang; Sung Pil Jo; Jiyun Lee; Jeong Keun Kim; Ki Hyun Kim; Young Hee Lim

doi:10.1016/j.jff.2015.09.039

Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Dahyun Hwang, Sung Pil Jo, Jiyun Lee, Jeong Keun Kim, Ki Hyun Kim, Young Hee Lim

Department of Public Health Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.

Original language	English
Pages (from-to)	353-362
Number of pages	10
Journal	Journal of Functional Foods
Volume	19
DOIs	https://doi.org/10.1016/j.jff.2015.09.039
Publication status	Published - 2015 Dec

Bibliographical note

Funding Information:
This research was supported by the High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea ( 313028-3 ).

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

Antihyperlipidaemia
Atherogenic index
Coronary artery risk index
Foam cell
Oxyresveratrol
Ramulus mori

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1016/j.jff.2015.09.039

Cite this

@article{f33827eb837c4e949955a4d380a9f9c0,

title = "Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet",

abstract = "The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.",

keywords = "Antihyperlipidaemia, Atherogenic index, Coronary artery risk index, Foam cell, Oxyresveratrol, Ramulus mori",

author = "Dahyun Hwang and Jo, {Sung Pil} and Jiyun Lee and Kim, {Jeong Keun} and Kim, {Ki Hyun} and Lim, {Young Hee}",

note = "Funding Information: This research was supported by the High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea ( 313028-3 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = dec,

doi = "10.1016/j.jff.2015.09.039",

language = "English",

volume = "19",

pages = "353--362",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

AU - Hwang, Dahyun

AU - Jo, Sung Pil

AU - Lee, Jiyun

AU - Kim, Jeong Keun

AU - Kim, Ki Hyun

AU - Lim, Young Hee

N1 - Funding Information: This research was supported by the High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea ( 313028-3 ). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/12

Y1 - 2015/12

N2 - The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.

AB - The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.

KW - Antihyperlipidaemia

KW - Atherogenic index

KW - Coronary artery risk index

KW - Foam cell

KW - Oxyresveratrol

KW - Ramulus mori

UR - http://www.scopus.com/inward/record.url?scp=84946401434&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2015.09.039

DO - 10.1016/j.jff.2015.09.039

M3 - Article

AN - SCOPUS:84946401434

SN - 1756-4646

VL - 19

SP - 353

EP - 362

JO - Journal of Functional Foods

JF - Journal of Functional Foods

ER -

Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this