Antihyperlipidemic Effects of Rhapontin and Rhapontigenin from Rheum undulatum in Rats Fed a High-Cholesterol Diet

Sung Pil Jo, Jeong Keun Kim, Young Hee Lim

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5mg/kg/day). Rhapontin and rhapontigenin treatment resulted in a significant (p<0.05) dose-dependent decrease in the serum lipid level, while the high-density lipoprotein cholesterol level increased slightly compared with the experimental control. Furthermore, rhapontin and rhapontigenin treatment improved the pathological characteristics of the degenerating fatty liver in high-cholesterol diet-induced hyperlipidemic rats dose-dependently. Aspartate aminotransferase and alanine aminotransferase levels in rhapontin- and rhapontigenin-treated hyperlipidemic rats were not significantly different from those in the control. These results indicate that rhapontin and rhapontigenin can be used as potent antihyperlipidemic agents.

    Original languageEnglish
    Pages (from-to)1067-1071
    Number of pages5
    JournalPlanta Medica
    Volume80
    Issue number13
    DOIs
    Publication statusPublished - 2014 Aug 1

    Keywords

    • antihyperlipidemic effect
    • high-cholesterol diet
    • methoxylated stilbene
    • Polygonaceae
    • Rheum undulatum

    ASJC Scopus subject areas

    • Drug Discovery
    • Pharmacology
    • Pharmaceutical Science
    • Analytical Chemistry
    • Organic Chemistry
    • Molecular Medicine
    • Complementary and alternative medicine
    • General Medicine

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