Abstract
Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5mg/kg/day). Rhapontin and rhapontigenin treatment resulted in a significant (p<0.05) dose-dependent decrease in the serum lipid level, while the high-density lipoprotein cholesterol level increased slightly compared with the experimental control. Furthermore, rhapontin and rhapontigenin treatment improved the pathological characteristics of the degenerating fatty liver in high-cholesterol diet-induced hyperlipidemic rats dose-dependently. Aspartate aminotransferase and alanine aminotransferase levels in rhapontin- and rhapontigenin-treated hyperlipidemic rats were not significantly different from those in the control. These results indicate that rhapontin and rhapontigenin can be used as potent antihyperlipidemic agents.
Original language | English |
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Pages (from-to) | 1067-1071 |
Number of pages | 5 |
Journal | Planta Medica |
Volume | 80 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2014 Aug 1 |
Keywords
- antihyperlipidemic effect
- high-cholesterol diet
- methoxylated stilbene
- Polygonaceae
- Rheum undulatum
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Pharmaceutical Science
- Analytical Chemistry
- Organic Chemistry
- Molecular Medicine
- Complementary and alternative medicine
- Medicine(all)