Antimicrobial Activities of the Anti-acne Compounds from Natural Sources

Eun Sil Nam, Kim, Narae, Young Hee Lim, Sul Woong Park

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-log]o-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6. l-logi0-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.

    Original languageEnglish
    Pages (from-to)80-84
    Number of pages5
    JournalKorean Journal of Microbiology and Biotechnology
    Volume37
    Issue number1
    Publication statusPublished - 2009 Mar

    Keywords

    • Anti-acne
    • Antimicrobial activity
    • Propionibacterium acnes

    ASJC Scopus subject areas

    • Biotechnology
    • Microbiology
    • Applied Microbiology and Biotechnology

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