Abstract
The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-log]o-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6. l-logi0-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.
| Original language | English |
|---|---|
| Pages (from-to) | 80-84 |
| Number of pages | 5 |
| Journal | Korean Journal of Microbiology and Biotechnology |
| Volume | 37 |
| Issue number | 1 |
| Publication status | Published - 2009 Mar |
Keywords
- Anti-acne
- Antimicrobial activity
- Propionibacterium acnes
ASJC Scopus subject areas
- Biotechnology
- Microbiology
- Applied Microbiology and Biotechnology