Antimicrobial cyclic peptides for plant disease control

Dong Wan Lee, Beom Seok Kim

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    Antimicrobial cyclic peptides derived from microbes bind stably with target sites, have a tolerance to hydrolysis by proteases, and a favorable degradability under field conditions, which make them an attractive proposition for use as agricultural fungicides. Antimicrobial cyclic peptides are classified according to the types of bonds within the ring structure; homodetic, heterodetic, and complex cyclic peptides, which in turn reflect diverse physicochemical features. Most antimicrobial cyclic peptides affect the integrity of the cell envelope. This is achieved through direct interaction with the cell membrane or disturbance of the cell wall and membrane component biosynthesis such as chitin, glucan, and sphingolipid. These are specific and selective targets providing reliable activity and safety for non-target organisms. Synthetic cyclic peptides produced through combinatorial chemistry offer an alternative approach to develop antimicrobials for agricultural uses. Those synthesized so far have been studied for antibacterial activity, however, the recent advancements in powerful technologies now promise to provide novel antimicrobial cyclic peptides that are yet to be discovered from natural resources.

    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalPlant Pathology Journal
    Volume31
    Issue number1
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

    Publisher Copyright:
    © The Korean Society of Plant Pathology.

    Keywords

    • Antimicrobial peptides
    • Cyclic peptides
    • Fungal diseases
    • Plant disease control

    ASJC Scopus subject areas

    • Agronomy and Crop Science

    Fingerprint

    Dive into the research topics of 'Antimicrobial cyclic peptides for plant disease control'. Together they form a unique fingerprint.

    Cite this