Antioxidative oligostilbenes from Caragana sinica

Qinghao Jin, Xiang Hua Han, Seong Su Hong, Chul Lee, Sanggil Choe, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC 50 values ranging from 34.7 ± 1.0 to 89.1 ± 2.3 μM.

Original languageEnglish
Pages (from-to)973-976
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number2
DOIs
Publication statusPublished - 2012 Jan 15

Bibliographical note

Funding Information:
This work was supported by the research grant of the Chungbuk National University in 2010.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Antioxidant activity
  • Caragana sinica
  • Fabaceae
  • Oligostilbenes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Antioxidative oligostilbenes from Caragana sinica'. Together they form a unique fingerprint.

Cite this