Antioxidative oligostilbenes from Caragana sinica

Qinghao Jin; Xiang Hua Han; Seong Su Hong; Chul Lee; Sanggil Choe; Dongho Lee; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2011.12.012

Antioxidative oligostilbenes from Caragana sinica

Qinghao Jin, Xiang Hua Han, Seong Su Hong, Chul Lee, Sanggil Choe, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC ₅₀ values ranging from 34.7 ± 1.0 to 89.1 ± 2.3 μM.

Original language	English
Pages (from-to)	973-976
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2011.12.012
Publication status	Published - 2012 Jan 15

Bibliographical note

Funding Information:
This work was supported by the research grant of the Chungbuk National University in 2010.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

Antioxidant activity
Caragana sinica
Fabaceae
Oligostilbenes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.12.012

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abstract = "Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC 50 values ranging from 34.7 ± 1.0 to 89.1 ± 2.3 μM.",

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AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

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KW - Fabaceae

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Antioxidative oligostilbenes from Caragana sinica

Abstract

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Keywords

ASJC Scopus subject areas

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