Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim, Kyu Won Cho, Seong Su Hong, Bang Yeon Hwang, Taehoon Chun, Dongho Lee

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
Publication statusPublished - 2015 Feb 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A6A3A01064888 ) and a Korea University Grant.

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.


  • Antiproliferative effect
  • Dictamnus dasycarpus
  • Glabretal-type triterpenoid
  • Rutaceae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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