Abstract
Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dose-dependent antiproliferative effect on P388D1 mouse lymphoma, F9 mouse teratocarcinoma, and DLD-1 human colon cancer cells with IC50 values of 11, 50, and 50 μg/ml, respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice, orally administered with 80 and 200 mg/kg/day of SSPs, was inhibited 10.3% and 52.4%, respectively, and survival days increased by 11.9% and 22.1%, respectively, compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.
Original language | English |
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Pages (from-to) | 628-630 |
Number of pages | 3 |
Journal | Journal of microbiology and biotechnology |
Volume | 14 |
Issue number | 3 |
Publication status | Published - 2004 Jun |
Keywords
- Antiproliferation
- Antitumor
- Korea soy sauce
- Peptide
- Teratocarcinoma
ASJC Scopus subject areas
- Biotechnology
- Applied Microbiology and Biotechnology