Antitumor activity of peptide fraction from traditional Korean soy sauce

Hong Jin Lee, Ki Won Lee, Kyoung Heon Kim, Hyun Kyung Kim, Hyong Joo Lee

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dose-dependent antiproliferative effect on P388D1 mouse lymphoma, F9 mouse teratocarcinoma, and DLD-1 human colon cancer cells with IC50 values of 11, 50, and 50 μg/ml, respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice, orally administered with 80 and 200 mg/kg/day of SSPs, was inhibited 10.3% and 52.4%, respectively, and survival days increased by 11.9% and 22.1%, respectively, compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.

Original languageEnglish
Pages (from-to)628-630
Number of pages3
JournalJournal of microbiology and biotechnology
Issue number3
Publication statusPublished - 2004 Jun


  • Antiproliferation
  • Antitumor
  • Korea soy sauce
  • Peptide
  • Teratocarcinoma

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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