Antitumor activity of peptide fraction from traditional Korean soy sauce

Hong Jin Lee, Ki Won Lee, Kyoung Heon Kim, Hyun Kyung Kim, Hyong Joo Lee

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dose-dependent antiproliferative effect on P388D1 mouse lymphoma, F9 mouse teratocarcinoma, and DLD-1 human colon cancer cells with IC50 values of 11, 50, and 50 μg/ml, respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice, orally administered with 80 and 200 mg/kg/day of SSPs, was inhibited 10.3% and 52.4%, respectively, and survival days increased by 11.9% and 22.1%, respectively, compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.

    Original languageEnglish
    Pages (from-to)628-630
    Number of pages3
    JournalJournal of microbiology and biotechnology
    Volume14
    Issue number3
    Publication statusPublished - 2004 Jun

    Keywords

    • Antiproliferation
    • Antitumor
    • Korea soy sauce
    • Peptide
    • Teratocarcinoma

    ASJC Scopus subject areas

    • Biotechnology
    • Applied Microbiology and Biotechnology

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