Abstract
IL-6 is a pleiotropic cytokine that is capable of modulating the diverse functions of hepatocytes such as acute phase responses and inflammation in the liver. To learn its antitumor effects in vivo, the cDNA of IL-6 was transfected into murine liver cells, TIB cells. IL-6-transfected TIB cells (TIB73-IL-6 or TIB75-IL-6) produced much higher levels of IL-6 compared with vector-transfected TIB cells (TIB73-vec or TIB75-vec). To investigate the effects of IL-6 on TIB tumor growth in vivo, IL-6-transfected TIB cells or vector-transfected TIB cells were injected subcutaneously into syngeneic mice. Vector-transfected TIB cells grew rapidly 3 weeks after injection, but IL-6-transfected TIB cells did not grow at all for up to 6 weeks. Pathologically, IL-6-transfected TIB cells demonstrated a severe necrosis and apoptotic pattern. Taken together, these results indicate that IL-6 functions as a growth inhibiting factor in vivo, and another biological role of IL-6 in the liver is suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 142-144 |
| Number of pages | 3 |
| Journal | Journal of Biomedical Science |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1999 |
| Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by grants (HAN Project HS2240 and KM 1241) from MOST, Republic of Korea.
Keywords
- Antitumor effects
- Host immunity
- Interleukin-6
- Liver tumor
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
- Biochemistry, medical
- Pharmacology (medical)
