Antiviral Activities of Trichothecenes Isolated from Trichoderma albolutescens against Pepper Mottle Virus

Seung Mok Ryu, Hae Min Lee, Eun Gyeong Song, Young Hye Seo, Jun Lee, Yuanqiang Guo, Beom Seok Kim, Jae Jin Kim, Jin Sung Hong, Ki Hyun Ryu, Dongho Lee

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


A bioassay-guided isolation using a green fluorescence protein (GFP)-tagged pepper mottle virus (PepMoV-GFP) based leaf-disk method to obtain new antiviral agents led to the isolation of trichodermin, 1, and a new compound trichoderminol, 2, from EtOAc extract of Trichoderma albolutescens culture medium. The structures of compounds 1 and 2 were determined by MS and NMR experiments, and the absolute configurations of the compounds were established by experimental and calculated vibrational circular dichroism spectra. Compounds 1 and 2 were evaluated for their anti-PepMoV potential in systemic host plants, such as tobacco and pepper, by PepMoV-GFP based systemic host method. All compounds exhibited inactivation effects against PepMoV. Furthermore, compound 1 showed protective effects against PepMoV.

Original languageEnglish
Pages (from-to)4273-4279
Number of pages7
JournalJournal of agricultural and food chemistry
Issue number21
Publication statusPublished - 2017 May 31

Bibliographical note

Funding Information:
This research was supported by a grant from the iPET (Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries, 115090021SB010) and a grant from National Research Foundation of Korea (NRF- 2015R1D1A1A01060321).

Publisher Copyright:
© 2017 American Chemical Society.


  • Capsicum annuum
  • Nicotiana benthamiana
  • Trichoderma albolutescens
  • antiviral agent
  • pepper mottle virus
  • trichothecene
  • vibrational circular dichroism

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


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