Apolipoprotein A5 3'-UTR variants and cardiometabolic traits in Koreans: Results from the Korean genome and epidemiology study and the korea national health and nutrition examination survey

Oh Yoen Kim, Jiyoung Moon, Garam Jo, So Young Kwak, Ji Young Kim, Min Jeong Shin

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


BACKGROUND/OBJECTIVES: This study aimed to test the association between APOA5 3'-UTR variants (rs662799) and cardiometabolic traits in Koreans. SUBJECTS/METHODS: For this study, epidemiological data, Apolipoprotein A5 (APOA5) genotype information, and lymphoblastoid cell line (LCL) biospecimens from a subset of the Ansung-Ansan cohort within the Korean Genome and Epidemiology study (KoGES-ASAS; n = 7,704) as well as epidemiological data along with genomic DNA biospecimens of participants from a subset of the Korea National Health and Nutrition Examination Survey (KNHANES 2011-12; n = 2,235) were obtained. APOA5 mRNA expression was also measured. RESULTS: APOA5 rs662799 genotype distributions in both the KoGES-ASAS and KNHANES groups were 50.6% for TT, 41.3% for TC, and 8.1% for CC, which are similar to those in previous reports. In both groups, minor C allele carriers, particularly subjects with CC homozygosity, had lower high-density lipoprotein (HDL) cholesterol and higher triglyceride levels than TT homozygotes. Linear regression analysis showed that the minor C allele significantly contributed to reduction of circulating HDL cholesterol levels [β = -2.048, P < 0.001; β = -2.199, P < 0.001] as well as elevation of circulating triglyceride levels [β = 0.053, P < 0.001; β = 0.066, P < 0.001] in both the KoGES-ASAS and KNHANES groups. In addition, higher expression levels of APOA5 in LCLs of 64 healthy individuals were negatively associated with body mass index (r = -0.277, P = 0.027) and circulating triglyceride level (r = -0.340, P = 0.006) but not significantly correlated with circulating HDL cholesterol level. On the other hand, we observed no significant difference in the mRNA level of APOA5 according to APOA5 rs662799 polymorphisms. CONCLUSIONS: The C allele of APOA5 rs662799 was found to be significantly associated with cardiometabolic traits in a large Korean population from the KoGES-ASAS and KNHANES. The effect of this genotype may be associated with post-transcriptional regulation, which deserves further experimental confirmation.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalNutrition Research and Practice
Issue number1
Publication statusPublished - 2018 Feb

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program, through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2015R1A2A1A15054758). §Corresponding Author: Min-Jeong Shin, Tel. 82-2-3290-5643, Fax. 82-2-940-2849, Email. mjshin@korea.ac.kr Received: October 23, 2017, Revised: December 16, 2017, Accepted: December 18, 2017 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher Copyright:
© 2018 The Korean Nutrition Society and the Korean Society of Community Nutrition.


  • Apolipoprotein A-V
  • Koreans
  • Metabolic syndrome
  • Triglycerides

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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