TY - JOUR
T1 - Apolipoprotein B is a better marker than non-HDL-cholesterol for the metabolic syndrome in Koreans
AU - Han, Jee Hye
AU - Park, Hye Soon
AU - Kim, Jeong A.
AU - Kim, Seon Mee
N1 - Funding Information:
This study was supported by a grant (10526) from the Korean Seoul City Research and Business Development Program.
PY - 2008/3
Y1 - 2008/3
N2 - Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. Non-HDL-cholesterol (non-HDL-C) has been considered a therapeutic target for patients with hypertriglyceridemia. We compared the predictive values of apoB and non-HDL-C for the metabolic syndrome (MetS) in 3335 Korean adults (mean age, 45.2 years) who participated consecutively in a health examination in a university hospital. Anthropometry, blood pressure, fasting glucose, lipid profiles and apoB were measured. MetS, as defined by a modification of the NCEP-ATP III criteria, was present in 22.1% of men and 16.1% of women. Among the components of the MetS, triglycerides showed the strongest correlation with apoB (r = 0.393, P < 0.001 in men, and r = 0.326, P < 0.001 in women) and non-HDL-C (r = 0.376, P < 0.001 in men, and r = 0.349, P < 0.001 in women). When apoB and non-HDL-C were mutually adjusted, the ORs for the MetS of non-HDL-C were not significant. As a function of the quartile of apoB levels, the ORs for the MetS were 2.04 (1.26-3.30), 3.54 (2.11-5.93), and 5.38 (3.16-9.17) in men (P for trend <0.001) and 3.75 (1.42-9.87), 5.55 (2.09-14.69), and 13.41 (5.02-35.79) in women (P for trend <0.001), respectively. These findings indicate that apoB is a better marker than non-HDL-C for identifying the MetS among Koreans.
AB - Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. Non-HDL-cholesterol (non-HDL-C) has been considered a therapeutic target for patients with hypertriglyceridemia. We compared the predictive values of apoB and non-HDL-C for the metabolic syndrome (MetS) in 3335 Korean adults (mean age, 45.2 years) who participated consecutively in a health examination in a university hospital. Anthropometry, blood pressure, fasting glucose, lipid profiles and apoB were measured. MetS, as defined by a modification of the NCEP-ATP III criteria, was present in 22.1% of men and 16.1% of women. Among the components of the MetS, triglycerides showed the strongest correlation with apoB (r = 0.393, P < 0.001 in men, and r = 0.326, P < 0.001 in women) and non-HDL-C (r = 0.376, P < 0.001 in men, and r = 0.349, P < 0.001 in women). When apoB and non-HDL-C were mutually adjusted, the ORs for the MetS of non-HDL-C were not significant. As a function of the quartile of apoB levels, the ORs for the MetS were 2.04 (1.26-3.30), 3.54 (2.11-5.93), and 5.38 (3.16-9.17) in men (P for trend <0.001) and 3.75 (1.42-9.87), 5.55 (2.09-14.69), and 13.41 (5.02-35.79) in women (P for trend <0.001), respectively. These findings indicate that apoB is a better marker than non-HDL-C for identifying the MetS among Koreans.
KW - Apolipoprotein B
KW - Korean
KW - Metabolic syndrome
KW - Non-HDL-cholesterol
KW - Prediction
UR - http://www.scopus.com/inward/record.url?scp=39449088821&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2007.05.021
DO - 10.1016/j.atherosclerosis.2007.05.021
M3 - Article
C2 - 17628565
AN - SCOPUS:39449088821
SN - 0021-9150
VL - 197
SP - 333
EP - 338
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -