Apoptosis is induced by Hantaviruses in cultured cells

Ju Il Kang, Se Hoon Park, Pyung Woo Lee, Byung Yoon Ahn

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52 Citations (Scopus)


Hantaviruses replicate in primary and cultured animal cells with little or no cytopathic effect. We report here that the cultured Vero E6 cells infected by the Hantaan or by the Prospect Hill viruses exhibited characteristic features of apoptosis, including condensation and segmentation of nuclei and internucleosomal cleavage of nuclear DNA. Apoptosis was not seen in the cells adsorbed by UV-inactivated virus, indicating that the viral replication is required for the induction of apoptosis. Furthermore, level of the proto-oncogenic Bcl-2 protein was significantly reduced, whereas its mRNA level remained unchanged in Hantaan virus-infected cells, suggesting possible involvement and posttranscriptional regulation of this antiapoptotic protein in the process.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
Issue number1
Publication statusPublished - 1999 Nov 10

Bibliographical note

Funding Information:
This work was supported by grants from the Ministry of Science and Technology (97N10201A17) and from the Ministry of Health (HMP98M20033) of Korea. The authors are grateful to Drs. S. D. Kim and E. J. Choi of the Korea University for their critical reading of the manuscript.

ASJC Scopus subject areas

  • Virology


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