Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome

Jae Won Hyun, Woojun Kim, So Young Huh, Min Su Park, Suk Won Ahn, Joong Yang Cho, Byung Jo Kim, Sang Hyun Lee, Su Hyun Kim, Ho Jin Kim

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    Objectives: To evaluate the validity of the revised 2017 McDonald criteria for multiple sclerosis (MS) compared with the 2010 McDonald criteria to predict conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). Methods: A total of 163 patients from seven referral hospitals in Korea, who experienced a first clinical event suggestive of MS between 2006 and 2017, were enrolled. Patients were stratified into two groups according to outcome at the last visit: CDMS converters who experienced a second clinical event and non-converters. Results: Of the 163 patients with a mean follow-up of 63 months, 60% converted to CDMS. The sensitivity, specificity, positive and negative predictive values and accuracy were, respectively, 88.8%, 43.1%, 70.2%, 71.8% and 70.6% for the 2017 McDonald criteria and 53.1%, 69.2%, 72.2%, 49.5% and 59.5% for the 2010 McDonald criteria. After exclusion of 82 patients who received disease-modifying agents before the second attack, the specificity of the 2017 and 2010 McDonald criteria increased to 85.0% and 95.0%, but sensitivity decreased to 83.6% and 47.5%, respectively. Conclusion: The 2017 McDonald criteria afforded higher sensitivity and accuracy but lower specificity compared with the 2010 McDonald criteria for prediction of conversion to CDMS in Korean CIS patients.

    Original languageEnglish
    Pages (from-to)1488-1495
    Number of pages8
    JournalMultiple Sclerosis Journal
    Volume25
    Issue number11
    DOIs
    Publication statusPublished - 2019 Oct 1

    Bibliographical note

    Funding Information:
    J.-W.H. and H.J.K. had full access to all of the data in the study; take responsibility for the integrity of the data and the accuracy of the data analysis; conceived the study concept and design; and performed drafting of the manuscript and statistical analysis. All authors performed the acquisition, analysis and interpretation of data, and critical revision of the manuscript for important intellectual content. The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the National Research Foundation of Korea (NRF-2017R1D1A1B03028868).

    Publisher Copyright:
    © The Author(s), 2018.

    Keywords

    • MRI
    • Multiple sclerosis
    • diagnosis

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

    Fingerprint

    Dive into the research topics of 'Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome'. Together they form a unique fingerprint.

    Cite this