Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome

Jae Won Hyun; Woojun Kim; So Young Huh; Min Su Park; Suk Won Ahn; Joong Yang Cho; Byung Jo Kim; Sang Hyun Lee; Su Hyun Kim; Ho Jin Kim

doi:10.1177/1352458518790702

Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome

Jae Won Hyun, Woojun Kim, So Young Huh, Min Su Park, Suk Won Ahn, Joong Yang Cho, Byung Jo Kim, Sang Hyun Lee, Su Hyun Kim, Ho Jin Kim

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Objectives: To evaluate the validity of the revised 2017 McDonald criteria for multiple sclerosis (MS) compared with the 2010 McDonald criteria to predict conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). Methods: A total of 163 patients from seven referral hospitals in Korea, who experienced a first clinical event suggestive of MS between 2006 and 2017, were enrolled. Patients were stratified into two groups according to outcome at the last visit: CDMS converters who experienced a second clinical event and non-converters. Results: Of the 163 patients with a mean follow-up of 63 months, 60% converted to CDMS. The sensitivity, specificity, positive and negative predictive values and accuracy were, respectively, 88.8%, 43.1%, 70.2%, 71.8% and 70.6% for the 2017 McDonald criteria and 53.1%, 69.2%, 72.2%, 49.5% and 59.5% for the 2010 McDonald criteria. After exclusion of 82 patients who received disease-modifying agents before the second attack, the specificity of the 2017 and 2010 McDonald criteria increased to 85.0% and 95.0%, but sensitivity decreased to 83.6% and 47.5%, respectively. Conclusion: The 2017 McDonald criteria afforded higher sensitivity and accuracy but lower specificity compared with the 2010 McDonald criteria for prediction of conversion to CDMS in Korean CIS patients.

Original language	English
Pages (from-to)	1488-1495
Number of pages	8
Journal	Multiple Sclerosis Journal
Volume	25
Issue number	11
DOIs	https://doi.org/10.1177/1352458518790702
Publication status	Published - 2019 Oct 1

Bibliographical note

Funding Information:
J.-W.H. and H.J.K. had full access to all of the data in the study; take responsibility for the integrity of the data and the accuracy of the data analysis; conceived the study concept and design; and performed drafting of the manuscript and statistical analysis. All authors performed the acquisition, analysis and interpretation of data, and critical revision of the manuscript for important intellectual content. The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the National Research Foundation of Korea (NRF-2017R1D1A1B03028868).

Publisher Copyright:
© The Author(s), 2018.

Keywords

MRI
Multiple sclerosis
diagnosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1177/1352458518790702

Cite this

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title = "Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome",

abstract = "Objectives: To evaluate the validity of the revised 2017 McDonald criteria for multiple sclerosis (MS) compared with the 2010 McDonald criteria to predict conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). Methods: A total of 163 patients from seven referral hospitals in Korea, who experienced a first clinical event suggestive of MS between 2006 and 2017, were enrolled. Patients were stratified into two groups according to outcome at the last visit: CDMS converters who experienced a second clinical event and non-converters. Results: Of the 163 patients with a mean follow-up of 63 months, 60% converted to CDMS. The sensitivity, specificity, positive and negative predictive values and accuracy were, respectively, 88.8%, 43.1%, 70.2%, 71.8% and 70.6% for the 2017 McDonald criteria and 53.1%, 69.2%, 72.2%, 49.5% and 59.5% for the 2010 McDonald criteria. After exclusion of 82 patients who received disease-modifying agents before the second attack, the specificity of the 2017 and 2010 McDonald criteria increased to 85.0% and 95.0%, but sensitivity decreased to 83.6% and 47.5%, respectively. Conclusion: The 2017 McDonald criteria afforded higher sensitivity and accuracy but lower specificity compared with the 2010 McDonald criteria for prediction of conversion to CDMS in Korean CIS patients.",

keywords = "MRI, Multiple sclerosis, diagnosis",

author = "Hyun, {Jae Won} and Woojun Kim and Huh, {So Young} and Park, {Min Su} and Ahn, {Suk Won} and Cho, {Joong Yang} and Kim, {Byung Jo} and Lee, {Sang Hyun} and Kim, {Su Hyun} and Kim, {Ho Jin}",

note = "Funding Information: J.-W.H. and H.J.K. had full access to all of the data in the study; take responsibility for the integrity of the data and the accuracy of the data analysis; conceived the study concept and design; and performed drafting of the manuscript and statistical analysis. All authors performed the acquisition, analysis and interpretation of data, and critical revision of the manuscript for important intellectual content. The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the National Research Foundation of Korea (NRF-2017R1D1A1B03028868). Publisher Copyright: {\textcopyright} The Author(s), 2018.",

year = "2019",

month = oct,

day = "1",

doi = "10.1177/1352458518790702",

language = "English",

volume = "25",

pages = "1488--1495",

journal = "Multiple Sclerosis Journal",

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T1 - Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome

AU - Hyun, Jae Won

AU - Kim, Woojun

AU - Huh, So Young

AU - Park, Min Su

AU - Ahn, Suk Won

AU - Cho, Joong Yang

AU - Kim, Byung Jo

AU - Lee, Sang Hyun

AU - Kim, Su Hyun

AU - Kim, Ho Jin

N1 - Funding Information: J.-W.H. and H.J.K. had full access to all of the data in the study; take responsibility for the integrity of the data and the accuracy of the data analysis; conceived the study concept and design; and performed drafting of the manuscript and statistical analysis. All authors performed the acquisition, analysis and interpretation of data, and critical revision of the manuscript for important intellectual content. The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the National Research Foundation of Korea (NRF-2017R1D1A1B03028868). Publisher Copyright: © The Author(s), 2018.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objectives: To evaluate the validity of the revised 2017 McDonald criteria for multiple sclerosis (MS) compared with the 2010 McDonald criteria to predict conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). Methods: A total of 163 patients from seven referral hospitals in Korea, who experienced a first clinical event suggestive of MS between 2006 and 2017, were enrolled. Patients were stratified into two groups according to outcome at the last visit: CDMS converters who experienced a second clinical event and non-converters. Results: Of the 163 patients with a mean follow-up of 63 months, 60% converted to CDMS. The sensitivity, specificity, positive and negative predictive values and accuracy were, respectively, 88.8%, 43.1%, 70.2%, 71.8% and 70.6% for the 2017 McDonald criteria and 53.1%, 69.2%, 72.2%, 49.5% and 59.5% for the 2010 McDonald criteria. After exclusion of 82 patients who received disease-modifying agents before the second attack, the specificity of the 2017 and 2010 McDonald criteria increased to 85.0% and 95.0%, but sensitivity decreased to 83.6% and 47.5%, respectively. Conclusion: The 2017 McDonald criteria afforded higher sensitivity and accuracy but lower specificity compared with the 2010 McDonald criteria for prediction of conversion to CDMS in Korean CIS patients.

AB - Objectives: To evaluate the validity of the revised 2017 McDonald criteria for multiple sclerosis (MS) compared with the 2010 McDonald criteria to predict conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). Methods: A total of 163 patients from seven referral hospitals in Korea, who experienced a first clinical event suggestive of MS between 2006 and 2017, were enrolled. Patients were stratified into two groups according to outcome at the last visit: CDMS converters who experienced a second clinical event and non-converters. Results: Of the 163 patients with a mean follow-up of 63 months, 60% converted to CDMS. The sensitivity, specificity, positive and negative predictive values and accuracy were, respectively, 88.8%, 43.1%, 70.2%, 71.8% and 70.6% for the 2017 McDonald criteria and 53.1%, 69.2%, 72.2%, 49.5% and 59.5% for the 2010 McDonald criteria. After exclusion of 82 patients who received disease-modifying agents before the second attack, the specificity of the 2017 and 2010 McDonald criteria increased to 85.0% and 95.0%, but sensitivity decreased to 83.6% and 47.5%, respectively. Conclusion: The 2017 McDonald criteria afforded higher sensitivity and accuracy but lower specificity compared with the 2010 McDonald criteria for prediction of conversion to CDMS in Korean CIS patients.

KW - MRI

KW - Multiple sclerosis

KW - diagnosis

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SN - 1352-4585

VL - 25

SP - 1488

EP - 1495

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 11

ER -

Application of the 2017 McDonald diagnostic criteria for multiple sclerosis in Korean patients with clinically isolated syndrome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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