Are hypoechoic lesions on transrectal ultrasonography a marker for clinically significant prostate cancer?

Purpose: To investigate the relationship of transrectal ultrasound (TRUS) findings with the pathological characteristics of prostate cancer (PCa). Materials andMethods: The study was conducted retrospectively by analyzing the data for 970 patients who underwent prostate biopsies. Gleason scores and other clinical variables were compared between PCa patients with and without hypoechoic lesions on TRUS. Results: Of the 970 patients, PCa was diagnosed in 291 (30%). Of these, high-grade PCa (Gleason score of 7 or more) was diagnosed in 190 (65%). The cancer detection rate was higher in patients with hypoechoic lesions (43.9%) than in those without hypoechoic lesions (21.4%, p<0.001). High-grade PCa was detected more often in patients with hypoechoic lesions than in those without hypoechoic lesions (p<0.001). Independent predictors for high-grade PCa by logistic regression analysis included hypoechoic le-sions on TRUS and abnormal digital rectal examination findings. Conclusions: Patients with PCa who had hypoechoic lesions on TRUS had more ag-gressive pathological disease than did those without lesions. Therefore, hypoechoic le-sions on TRUS could be a marker for clinically significant PCa.