Are posterior default-mode networks more robust than anterior default-mode networks? Evidence from resting-state fMRI data analysis

Dong Youl Kim; Jong Hwan Lee

doi:10.1016/j.neulet.2011.04.062

Are posterior default-mode networks more robust than anterior default-mode networks? Evidence from resting-state fMRI data analysis

Dong Youl Kim
, Jong Hwan Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Intrinsic brain activity known as default-mode networks (DMNs) has been observed predominantly within the medial/superior frontal areas, anterior/posterior cingulate gyri, and precuneus using blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI). Despite anecdotal evidence of distinct spatial patterns reflecting neuropsychiatric conditions in these DMNs, rigorous analysis of the characteristic traits of DMNs has been limited in previous studies. In this letter, the reproducibility and potential variability of the anterior and posterior DMNs were evaluated based on individual-level variations in effect sizes, activated areas, and causal interactions. Our results indicated that the DMNs were indeed reproducible between sessions/subjects. Region-specific traits were also observed: the posterior DMN seemed more robust to individual-level variations than the anterior DMN. The proposed analytical methods and reported findings may be useful in the development of a wide range of applications, including those involving clinical populations, which utilize the characteristic traits of DMNs.

Original language	English
Pages (from-to)	57-62
Number of pages	6
Journal	Neuroscience Letters
Volume	498
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.04.062
Publication status	Published - 2011 Jul 1

Bibliographical note

Funding Information:
This research was supported by World Class University program funded by the Ministry of Education, Science and Technology through the National Research Foundation (NRF) of Korea (R31-10008) and Basic Science Research Program, NRF grant of Korea (2011-0004794). These sponsors had no involvement in processes including the study design, data collection, analysis/interpretation of data, writing of the report, and decision to submit the paper for publication

Keywords

Default-mode networks
Effective connectivity
Functional MRI
Functional connectivity
Granger causality analysis
Group independent component analysis
Reproducibility
Resting-state networks

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2011.04.062

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title = "Are posterior default-mode networks more robust than anterior default-mode networks? Evidence from resting-state fMRI data analysis",

abstract = "Intrinsic brain activity known as default-mode networks (DMNs) has been observed predominantly within the medial/superior frontal areas, anterior/posterior cingulate gyri, and precuneus using blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI). Despite anecdotal evidence of distinct spatial patterns reflecting neuropsychiatric conditions in these DMNs, rigorous analysis of the characteristic traits of DMNs has been limited in previous studies. In this letter, the reproducibility and potential variability of the anterior and posterior DMNs were evaluated based on individual-level variations in effect sizes, activated areas, and causal interactions. Our results indicated that the DMNs were indeed reproducible between sessions/subjects. Region-specific traits were also observed: the posterior DMN seemed more robust to individual-level variations than the anterior DMN. The proposed analytical methods and reported findings may be useful in the development of a wide range of applications, including those involving clinical populations, which utilize the characteristic traits of DMNs.",

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note = "Funding Information: This research was supported by World Class University program funded by the Ministry of Education, Science and Technology through the National Research Foundation (NRF) of Korea (R31-10008) and Basic Science Research Program, NRF grant of Korea (2011-0004794). These sponsors had no involvement in processes including the study design, data collection, analysis/interpretation of data, writing of the report, and decision to submit the paper for publication ",

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N2 - Intrinsic brain activity known as default-mode networks (DMNs) has been observed predominantly within the medial/superior frontal areas, anterior/posterior cingulate gyri, and precuneus using blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI). Despite anecdotal evidence of distinct spatial patterns reflecting neuropsychiatric conditions in these DMNs, rigorous analysis of the characteristic traits of DMNs has been limited in previous studies. In this letter, the reproducibility and potential variability of the anterior and posterior DMNs were evaluated based on individual-level variations in effect sizes, activated areas, and causal interactions. Our results indicated that the DMNs were indeed reproducible between sessions/subjects. Region-specific traits were also observed: the posterior DMN seemed more robust to individual-level variations than the anterior DMN. The proposed analytical methods and reported findings may be useful in the development of a wide range of applications, including those involving clinical populations, which utilize the characteristic traits of DMNs.

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Are posterior default-mode networks more robust than anterior default-mode networks? Evidence from resting-state fMRI data analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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