Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses

Sehee Park; Jin Il Kim; Ilseob Lee; Sangmoo Lee; Min Woong Hwang; Joon Yong Bae; Jun Heo; Donghwan Kim; Sang Zin Han; Man Seong Park

doi:10.1016/j.bbrc.2013.08.090

Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses

Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min Woong Hwang, Joon Yong Bae, Jun Heo, Donghwan Kim, Sang Zin Han, Man Seong Park

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

The influenza virus is highly contagious in human populations around the world and results in approximately 250,000-500,000 deaths annually. Vaccines and antiviral drugs are commonly used to protect susceptible individuals. However, the antigenic mismatch of vaccines and the emergence of resistant strains against the currently available antiviral drugs have generated an urgent necessity to develop a novel broad-spectrum anti-influenza agent. Here we report that Aronia melanocarpa (black chokeberry, Aronia), the fruit of a perennial shrub species that contains several polyphenolic constituents, possesses in vitro and in vivo efficacy against different subtypes of influenza viruses including an oseltamivir-resistant strain. These anti-influenza properties of Aronia were attributed to two constituents, ellagic acid and myricetin. In an in vivo therapeutic mouse model, Aronia, ellagic acid, and myricetin protected mice against lethal challenge. Based on these results, we suggest that Aronia is a valuable source for antiviral agents and that ellagic acid and myricetin have potential as influenza therapeutics.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	440
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2013.08.090
Publication status	Published - 2013 Oct 11

Bibliographical note

Funding Information:
This study was supported by grants from the Korea Healthcare Technology R&D Project of the Ministry of Health & Welfare (Grant No. A103001 ), the Medical Research Center Program of National Research Foundation of Korea (Grant No. R13-2005-022-02002 ), and Hallym University Specialization Fund (Grant No. HRF-S-41 ). We would like to thank Dr. Chun Kang (Division of Influenza Viruses, KCDC, Osong, Republic of Korea), Dr. Peter Palese and Dr. Adolfo García-Sastre (Department of Microbiology, Mount Sinai School of Medicine, New York, NY) for providing us with viruses and reagents.

Keywords

Antiviral
Influenza virus
Polyphenol
Therapeutics

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2013.08.090

Cite this

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title = "Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses",

abstract = "The influenza virus is highly contagious in human populations around the world and results in approximately 250,000-500,000 deaths annually. Vaccines and antiviral drugs are commonly used to protect susceptible individuals. However, the antigenic mismatch of vaccines and the emergence of resistant strains against the currently available antiviral drugs have generated an urgent necessity to develop a novel broad-spectrum anti-influenza agent. Here we report that Aronia melanocarpa (black chokeberry, Aronia), the fruit of a perennial shrub species that contains several polyphenolic constituents, possesses in vitro and in vivo efficacy against different subtypes of influenza viruses including an oseltamivir-resistant strain. These anti-influenza properties of Aronia were attributed to two constituents, ellagic acid and myricetin. In an in vivo therapeutic mouse model, Aronia, ellagic acid, and myricetin protected mice against lethal challenge. Based on these results, we suggest that Aronia is a valuable source for antiviral agents and that ellagic acid and myricetin have potential as influenza therapeutics.",

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author = "Sehee Park and Kim, {Jin Il} and Ilseob Lee and Sangmoo Lee and Hwang, {Min Woong} and Bae, {Joon Yong} and Jun Heo and Donghwan Kim and Han, {Sang Zin} and Park, {Man Seong}",

note = "Funding Information: This study was supported by grants from the Korea Healthcare Technology R&D Project of the Ministry of Health & Welfare (Grant No. A103001 ), the Medical Research Center Program of National Research Foundation of Korea (Grant No. R13-2005-022-02002 ), and Hallym University Specialization Fund (Grant No. HRF-S-41 ). We would like to thank Dr. Chun Kang (Division of Influenza Viruses, KCDC, Osong, Republic of Korea), Dr. Peter Palese and Dr. Adolfo Garc{\'i}a-Sastre (Department of Microbiology, Mount Sinai School of Medicine, New York, NY) for providing us with viruses and reagents.",

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AU - Park, Sehee

AU - Kim, Jin Il

AU - Lee, Ilseob

AU - Lee, Sangmoo

AU - Hwang, Min Woong

AU - Bae, Joon Yong

AU - Heo, Jun

AU - Kim, Donghwan

AU - Han, Sang Zin

AU - Park, Man Seong

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PY - 2013/10/11

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N2 - The influenza virus is highly contagious in human populations around the world and results in approximately 250,000-500,000 deaths annually. Vaccines and antiviral drugs are commonly used to protect susceptible individuals. However, the antigenic mismatch of vaccines and the emergence of resistant strains against the currently available antiviral drugs have generated an urgent necessity to develop a novel broad-spectrum anti-influenza agent. Here we report that Aronia melanocarpa (black chokeberry, Aronia), the fruit of a perennial shrub species that contains several polyphenolic constituents, possesses in vitro and in vivo efficacy against different subtypes of influenza viruses including an oseltamivir-resistant strain. These anti-influenza properties of Aronia were attributed to two constituents, ellagic acid and myricetin. In an in vivo therapeutic mouse model, Aronia, ellagic acid, and myricetin protected mice against lethal challenge. Based on these results, we suggest that Aronia is a valuable source for antiviral agents and that ellagic acid and myricetin have potential as influenza therapeutics.

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Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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