TY - JOUR
T1 - Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy
AU - Kong, Na
AU - Zhang, Hanjie
AU - Feng, Chan
AU - Liu, Chuang
AU - Xiao, Yufen
AU - Zhang, Xingcai
AU - Mei, Lin
AU - Kim, Jong Seung
AU - Tao, Wei
AU - Ji, Xiaoyuan
N1 - Funding Information:
We acknowledge the supports from National Natural Science Foundation of China (Grant Nos. 81801826, 32071322; to X.J.), the US METAvivor Early Career Investigator Award (No. 2018A020560; to W.T.), Harvard Medical School/Brigham and Women’s Hospital Department of Anesthesiology Basic Scientist Grant (No. 2420 BPA075; to W.T.) and Center for Nanomedicine Research Fund (No. 2019A014810; to W.T.). W.T. is a recipient of the Khoury Innovation Award (No. 2020A003219), Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award (No. 113548), and American Heart Association (AHA) Collaborative Science Award (No. 2018A004190). W.T. also received a start-up package (for 3 years) from the Department of Anesthesiology, Perioperative and Pain Medicine to establish his independent research laboratory at Harvard Medical School and Brigham and Women’s Hospital.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient ·O2− and 1O2 production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating ·OH and O2 from H2O2, but also inactivates main anti-oxidants to cut off the “retreat routes” of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy.
AB - The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient ·O2− and 1O2 production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating ·OH and O2 from H2O2, but also inactivates main anti-oxidants to cut off the “retreat routes” of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85112489654&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-24961-5
DO - 10.1038/s41467-021-24961-5
M3 - Article
C2 - 34362904
AN - SCOPUS:85112489654
SN - 2041-1723
VL - 12
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 4777
ER -
