Abstract
Association of urinary arsenic concentration with incident diabetes was examined in American Indians from Arizona who have a high prevalence of type 2 diabetes and were screened for diabetes between 1982 and 2007. The population resides where drinking water contains arsenic at concentrations above federally recommended limits. A total of 150 nondiabetic subjects aged ≥25 years who subsequently developed type 2 diabetes were matched by year of examination and sex to 150 controls who remained nondiabetic for ≥10 years. Total urinary arsenic concentration, adjusted for urinary creatinine level, ranged from 6.6 μg/L to 123.1 μg/L, and inorganic arsenic concentration ranged from 0.1 μg/L to 36.0 μg/L. In logistic regression models adjusted for age, sex, body mass index, and urinary creatinine level, the odds ratios for incident diabetes were 1.11 (95% confidence interval (CI): 0.79, 1.57) and 1.16 (95% CI: 0.89, 1.53) for a 2-fold increase in total arsenic and inorganic arsenic, respectively. Categorical analyses suggested a positive relationship between quartiles of inorganic arsenic and incident diabetes (P = 0.056); post-hoc comparison of quartiles 2-4 with quartile 1 revealed 2-fold higher odds of diabetes in the upper quartiles (OR = 2.14, 95% CI: 1.19, 3.85). Modestly elevated exposure to inorganic arsenic may predict type 2 diabetes in American Indians. Larger studies that include measures of speciated arsenic are required for confirmation.
Original language | English |
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Pages (from-to) | 962-969 |
Number of pages | 8 |
Journal | American journal of epidemiology |
Volume | 177 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2013 May 1 |
Externally published | Yes |
Keywords
- Indians, North American
- arsenic
- diabetes mellitus, type 2
- incidence
- nested case-control studies
ASJC Scopus subject areas
- Epidemiology