Articular cartilage regeneration with microfracture and hyaluronic acid

Sun Woong Kang; Leela Prasad Bada; Chang Seok Kang; Jae Sun Lee; Chul Hwan Kim; Jung Ho Park; Byung Soo Kim

doi:10.1007/s10529-007-9576-2

Articular cartilage regeneration with microfracture and hyaluronic acid

Sun Woong Kang, Leela Prasad Bada, Chang Seok Kang, Jae Sun Lee, Chul Hwan Kim, Jung Ho Park, Byung Soo Kim

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-β3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.

Original language	English
Pages (from-to)	435-439
Number of pages	5
Journal	Biotechnology letters
Volume	30
Issue number	3
DOIs	https://doi.org/10.1007/s10529-007-9576-2
Publication status	Published - 2008 Mar

Bibliographical note

Funding Information:
Acknowledgement This work was supported by a research fund from Hanyang University (HY-2006-I), South Korea.

Keywords

Cartilage regeneration
Hyaluronic acid
Microfracture
Tissue engineering
Transforming growth factor-beta

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1007/s10529-007-9576-2

Cite this

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title = "Articular cartilage regeneration with microfracture and hyaluronic acid",

abstract = "Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-β3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.",

keywords = "Cartilage regeneration, Hyaluronic acid, Microfracture, Tissue engineering, Transforming growth factor-beta",

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AU - Bada, Leela Prasad

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AU - Lee, Jae Sun

AU - Kim, Chul Hwan

AU - Park, Jung Ho

AU - Kim, Byung Soo

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N2 - Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-β3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.

AB - Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-β3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.

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KW - Hyaluronic acid

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KW - Transforming growth factor-beta

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Articular cartilage regeneration with microfracture and hyaluronic acid

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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