TY - JOUR
T1 - Assessment of adverse impacts of glyphosate-based herbicide, Excel Mera 71 by integrating multi-level biomarker responses in fishes
AU - Samanta, P.
AU - Pal, S.
AU - Mukherjee, A. K.
AU - Senapati, T.
AU - Jung, J.
AU - Ghosh, A. R.
N1 - Funding Information:
Authors are thankful to Department of Science & Technology, India (DST/INSPIRE Fellowship/2011/164), for financial support. Presently, Dr Samanta joined Incheon National University as researcher. Authors are grateful to reviewers for improving the paper.
Publisher Copyright:
© 2018, Islamic Azad University (IAU).
PY - 2019/10/1
Y1 - 2019/10/1
N2 - This work was aimed to investigate the adverse impacts of Excel Mera 71 on Anabas testudineus, Heteropneustes fossilis and Oreochromis niloticus under laboratory (17.2 mg/L) and field (750 g/acre) conditions based on multiple-level integrated biomarker responses. Haematological parameters were influenced significantly and showed species specificity after Excel Mera 71 exposure under both the conditions. Physiological indices (hepato-somatic index and condition factor) showed higher values; however, hepato-somatic index induced significantly under both the conditions (p < 0.05). Total nuclear abnormalities at molecular level revealed enhanced level. Responses were more adverse in laboratory (O. niloticus > H. fossilis > A. testudineus), while total nuclear abnormalities under field showed the order as: H. fossilis (0.49 ± 0.08) > A. testudineus (0.46 ± 0.10) > O. niloticus (0.27 ± 0.05). Moreover, multi-level integrated biomarker responses displayed responses as: O. niloticus (6.97 fold) > H. fossilis (4.01 fold) > A. testudineus (2.33 fold) in laboratory; however, under field condition, responses were totally different [A. testudineus–H. fossilis (3.98 fold) > O. niloticus (3.01 fold)]. Additionally, glyphosate concentration was significantly correlated with several multi-level biomarker responses (p < 0.05). Moreover, multi-level integrated biomarker responses clearly indicated the higher impacts under laboratory experiment. Present investigation documented that multi-level integrative biomarker responses should be considered as reliable tool for assessment of herbicidal intoxication.
AB - This work was aimed to investigate the adverse impacts of Excel Mera 71 on Anabas testudineus, Heteropneustes fossilis and Oreochromis niloticus under laboratory (17.2 mg/L) and field (750 g/acre) conditions based on multiple-level integrated biomarker responses. Haematological parameters were influenced significantly and showed species specificity after Excel Mera 71 exposure under both the conditions. Physiological indices (hepato-somatic index and condition factor) showed higher values; however, hepato-somatic index induced significantly under both the conditions (p < 0.05). Total nuclear abnormalities at molecular level revealed enhanced level. Responses were more adverse in laboratory (O. niloticus > H. fossilis > A. testudineus), while total nuclear abnormalities under field showed the order as: H. fossilis (0.49 ± 0.08) > A. testudineus (0.46 ± 0.10) > O. niloticus (0.27 ± 0.05). Moreover, multi-level integrated biomarker responses displayed responses as: O. niloticus (6.97 fold) > H. fossilis (4.01 fold) > A. testudineus (2.33 fold) in laboratory; however, under field condition, responses were totally different [A. testudineus–H. fossilis (3.98 fold) > O. niloticus (3.01 fold)]. Additionally, glyphosate concentration was significantly correlated with several multi-level biomarker responses (p < 0.05). Moreover, multi-level integrated biomarker responses clearly indicated the higher impacts under laboratory experiment. Present investigation documented that multi-level integrative biomarker responses should be considered as reliable tool for assessment of herbicidal intoxication.
KW - Excel Mera 71
KW - Genotoxicity
KW - Haematology
KW - Hepato-somatic index
KW - Total nuclear abnormalities
UR - http://www.scopus.com/inward/record.url?scp=85053757864&partnerID=8YFLogxK
U2 - 10.1007/s13762-018-2013-3
DO - 10.1007/s13762-018-2013-3
M3 - Article
AN - SCOPUS:85053757864
SN - 1735-1472
VL - 16
SP - 6291
EP - 6300
JO - International Journal of Environmental Science and Technology
JF - International Journal of Environmental Science and Technology
IS - 10
ER -