Assessment of resistance to paclitaxel of murine tumors by 99mTc-MIBI/201Tl dual-radionuclide imaging

Noboru Oriuchi; Tatsuo Jibu; Luka Milas; Jae Gol Choe; Li Ren Kuang; E. Edmund Kim; Nancy R. Hunter; Sidney Wallace; Donald A. Podoloff

doi:10.1016/S0969-8051(99)00099-2

Assessment of resistance to paclitaxel of murine tumors by ^99mTc-MIBI/²⁰¹Tl dual-radionuclide imaging

Noboru Oriuchi, Tatsuo Jibu, Luka Milas, Jae Gol Choe, Li Ren Kuang, E. Edmund Kim, Nancy R. Hunter, Sidney Wallace, Donald A. Podoloff

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated P-glycoprotein (Pgp) expression by murine tumors with and without resistance to paclitaxel and the role of ^99mTc-2-methoxyisobutylisonitrile (MIBI)/²⁰¹Tl imaging in predicting the effect of paclitaxel. Antitumor effect of paclitaxel and biodistribution of the radiopharmaceuticals were evaluated in mice bearing four tumor types. Pgp expression did not correlate with the antitumor efficacy of paclitaxel. Although the absolute uptake of ^99mTc-MIBI did not correlate with Pgp expression, ^99mTc-MIBI could predict paclitaxel sensitivity by its higher uptake. Copyright (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	127-133
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/S0969-8051(99)00099-2
Publication status	Published - 2000 Feb

Keywords

Multidrug resistance
P-glycoprotein
Paclitaxel
Tc-sestamibi

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0969-8051(99)00099-2

Cite this

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title = "Assessment of resistance to paclitaxel of murine tumors by 99mTc-MIBI/201Tl dual-radionuclide imaging",

abstract = "This study investigated P-glycoprotein (Pgp) expression by murine tumors with and without resistance to paclitaxel and the role of 99mTc-2-methoxyisobutylisonitrile (MIBI)/201Tl imaging in predicting the effect of paclitaxel. Antitumor effect of paclitaxel and biodistribution of the radiopharmaceuticals were evaluated in mice bearing four tumor types. Pgp expression did not correlate with the antitumor efficacy of paclitaxel. Although the absolute uptake of 99mTc-MIBI did not correlate with Pgp expression, 99mTc-MIBI could predict paclitaxel sensitivity by its higher uptake. Copyright (C) 2000 Elsevier Science Inc.",

keywords = "Multidrug resistance, P-glycoprotein, Paclitaxel, Tc-sestamibi",

author = "Noboru Oriuchi and Tatsuo Jibu and Luka Milas and Choe, {Jae Gol} and Kuang, {Li Ren} and Kim, {E. Edmund} and Hunter, {Nancy R.} and Sidney Wallace and Podoloff, {Donald A.}",

year = "2000",

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doi = "10.1016/S0969-8051(99)00099-2",

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T1 - Assessment of resistance to paclitaxel of murine tumors by 99mTc-MIBI/201Tl dual-radionuclide imaging

AU - Oriuchi, Noboru

AU - Jibu, Tatsuo

AU - Milas, Luka

AU - Choe, Jae Gol

AU - Kuang, Li Ren

AU - Kim, E. Edmund

AU - Hunter, Nancy R.

AU - Wallace, Sidney

AU - Podoloff, Donald A.

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Y1 - 2000/2

N2 - This study investigated P-glycoprotein (Pgp) expression by murine tumors with and without resistance to paclitaxel and the role of 99mTc-2-methoxyisobutylisonitrile (MIBI)/201Tl imaging in predicting the effect of paclitaxel. Antitumor effect of paclitaxel and biodistribution of the radiopharmaceuticals were evaluated in mice bearing four tumor types. Pgp expression did not correlate with the antitumor efficacy of paclitaxel. Although the absolute uptake of 99mTc-MIBI did not correlate with Pgp expression, 99mTc-MIBI could predict paclitaxel sensitivity by its higher uptake. Copyright (C) 2000 Elsevier Science Inc.

AB - This study investigated P-glycoprotein (Pgp) expression by murine tumors with and without resistance to paclitaxel and the role of 99mTc-2-methoxyisobutylisonitrile (MIBI)/201Tl imaging in predicting the effect of paclitaxel. Antitumor effect of paclitaxel and biodistribution of the radiopharmaceuticals were evaluated in mice bearing four tumor types. Pgp expression did not correlate with the antitumor efficacy of paclitaxel. Although the absolute uptake of 99mTc-MIBI did not correlate with Pgp expression, 99mTc-MIBI could predict paclitaxel sensitivity by its higher uptake. Copyright (C) 2000 Elsevier Science Inc.

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KW - P-glycoprotein

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KW - Tc-sestamibi

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