Objective The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma. Methods A meta-analysis stratified by ethnicity and age was conducted on associations between the ADAM33 T1, T2, and ST+7 polymorphisms and asthma. Results Eleven studies, which included 4,124 patients and 7,094 controls, were available for the meta-analysis. Metaanalysis revealed an association between asthma and the ADAM33 T1 GG genotype [odds ratio (OR) = 2.257, 95 % confidence interval (CI) = 1.577-3.228, p = 8.42 × 10-7]. Stratification by ethnicity indicated an association between this genotype and asthma in Asians (OR = 2.683, 95 % CI = 1.799-4.001, p = 1.31 × 10-7), and stratification by age indicated an association between it and asthma in adults (OR = 1.895, 95 % CI = 1.005-3.573, p = 0.048). However, no association was found between asthma and the ADAM33 T2 and ST+7 polymorphisms. Conclusions This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no associationwas found between theADAM33 T2 and ST+7 polymorphisms and asthma susceptibility.
Bibliographical noteFunding Information:
This study is supported by a Korea University
Copyright 2013 Elsevier B.V., All rights reserved.
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