TY - JOUR
T1 - Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children
AU - Yun, Kyung Eun
AU - Kim, Seon Mee
AU - Choi, Kyung Mook
AU - Park, Hye Soon
N1 - Funding Information:
This study was supported by a grant from the Asan Institute for Life Science 2007-106.
PY - 2009/6
Y1 - 2009/6
N2 - Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. One hundred sixty-one 9-year-old Korean children (80 boys and 81 girls) voluntarily participated in this study at school-based health examinations. Weight, height, waist circumference, and blood pressure were measured. Fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, insulin, and A-FABP levels were measured; and insulin resistance was estimated by the homeostasis model assessment. Subjects with higher body mass index (BMI) percentiles had correspondingly higher concentrations of A-FABP in both boys and girls. Subjects within the highest quartile of A-FABP levels had correspondingly poor metabolic risk profiles (BMI, waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance) compared with those in the lowest A-FABP quartile (P < .01). Serum A-FABP concentrations were significantly correlated with BMI (r = 0.58, P < .01) and waist circumference (r = 0.51, P < .01). However, the significant correlation between serum A-FABP and insulin resistance faded after adjustment for BMI. Adipocyte fatty acid-binding protein was closely associated with obesity or abdominal obesity in children; however, the independent relationship between A-FABP and insulin resistance in children is still unclear and remains to be determined.
AB - Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. One hundred sixty-one 9-year-old Korean children (80 boys and 81 girls) voluntarily participated in this study at school-based health examinations. Weight, height, waist circumference, and blood pressure were measured. Fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, insulin, and A-FABP levels were measured; and insulin resistance was estimated by the homeostasis model assessment. Subjects with higher body mass index (BMI) percentiles had correspondingly higher concentrations of A-FABP in both boys and girls. Subjects within the highest quartile of A-FABP levels had correspondingly poor metabolic risk profiles (BMI, waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance) compared with those in the lowest A-FABP quartile (P < .01). Serum A-FABP concentrations were significantly correlated with BMI (r = 0.58, P < .01) and waist circumference (r = 0.51, P < .01). However, the significant correlation between serum A-FABP and insulin resistance faded after adjustment for BMI. Adipocyte fatty acid-binding protein was closely associated with obesity or abdominal obesity in children; however, the independent relationship between A-FABP and insulin resistance in children is still unclear and remains to be determined.
UR - http://www.scopus.com/inward/record.url?scp=65549106974&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2009.01.017
DO - 10.1016/j.metabol.2009.01.017
M3 - Article
C2 - 19368945
AN - SCOPUS:65549106974
SN - 0026-0495
VL - 58
SP - 798
EP - 802
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 6
ER -
