TY - JOUR
T1 - Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population
AU - Ro, M.
AU - Kim, S.
AU - Pyun, J. A.
AU - Shin, C.
AU - Cho, N. H.
AU - Lee, J. Y.
AU - Koh, I.
AU - Kwack, K.
PY - 2012/8
Y1 - 2012/8
N2 - Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC 4, LTD 4, LTE 4 and LTB 4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV 1_%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV 1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV 1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value<0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.
AB - Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC 4, LTD 4, LTE 4 and LTB 4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV 1_%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV 1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV 1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value<0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.
UR - http://www.scopus.com/inward/record.url?scp=84864305293&partnerID=8YFLogxK
U2 - 10.1111/j.1365-3083.2012.02712.x
DO - 10.1111/j.1365-3083.2012.02712.x
M3 - Article
C2 - 22537113
AN - SCOPUS:84864305293
SN - 0300-9475
VL - 76
SP - 151
EP - 157
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
IS - 2
ER -
